Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent,Macromolecular Bioscience

当前位置： X-MOL 学术 › Macromol. Biosci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Smart Titanium Coating Composed of Antibiotic Conjugated Peptides as an Infection‐Responsive Antibacterial Agent
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-10-13 , DOI: 10.1002/mabi.202000194
Yunfei Zhang ₁ , Kuan Hu ₂ , Xuan Xing ₁ , Jingshuang Zhang ₃ , Ming-Rong Zhang ₂ , Xiaohui Ma ₄ , Rui Shi ₃ , Liqun Zhang ₁

Affiliation

Antibacterial coating is rapidly emerging as a pivotal strategy for mitigating spread of bacterial pathogens. However, many challenges still need to be overcome in order to develop a smart coating that can achieve on‐demand antibacterial effects. In this study, a Staphylococcus aureus (S. aureus) sensitive peptide sequence is designed, and an antibiotic is then conjugated with this tailor‐made peptide. The antibiotic‐peptide conjugate is then linked to the surface of a titanium implant, where the peptide can be recognized and cleaved by an enzyme secreted by S. aureus. This allows for the release of antibiotics in the presence of S. aureus, thus achieving delivery of an antibacterial specifically when an infection occurs.

中文翻译：

由抗生素共轭肽组成的智能钛涂层作为感染反应性抗菌剂

抗菌涂层正迅速成为减轻细菌病原体传播的关键策略。然而，为了开发一种能够实现按需抗菌效果的智能涂层，仍然需要克服许多挑战。在这项研究中，设计了金黄色葡萄球菌( S. aureus ) 敏感肽序列，然后将抗生素与这种定制的肽结合。然后将抗生素-肽结合物连接到钛植入物的表面，在那里肽可以被金黄色葡萄球菌分泌的酶识别和切割。这允许在金黄色葡萄球菌存在时释放抗生素，从而在发生感染时实现抗菌剂的递送。

更新日期：2020-10-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11