Periodontitis is commonly diagnosed based on clinical parameters. However, the analysis of a few unique biomarkers of the disease process present in the saliva and blood can further assist the estimation of the rate of disease progression.

Aim

The present study attempted to correlate the alkaline phosphatase (ALP) and acid phosphatase (ACP) levels in saliva and serum between patients with healthy periodontium, gingivitis, and chronic periodontitis.

Materials and methods

The present study was conducted in 135 subjects between 20 and 55 years of age. The subjects were divided into three groups, namely healthy (Group A), gingivitis (Group B), and chronic periodontitis (Group C). The clinical parameters were recorded using the plaque index (PI), gingival index (GI), and probing depth (PD). Saliva and serum were analyzed for ALP and ACP levels using an auto analyzer. All patients underwent scaling and root planning (SRP) along with oral hygiene instructions. Patients were then recalled after four weeks, and blood and saliva samples were collected to estimate ALP and ACP levels prior to clinical examination.

Results

The clinical parameters exhibited a statistically significant decrease in the PI and GI in both group B and group C after SRP. A significant change in the PD and attachment levels (AL) was observed in the periodontitis group after SRP. The mean salivary & serum ALP levels exhibited a statistically significant decrease in group B & C after SRP. The mean serum ACP levels exhibited a statistically significant decrease in group B & C after SRP However, the salivary ACP levels decrease after SRP was only statistically significant in group C.

Conclusion

Serum and salivary ALP and ACP levels were markedly decreased in the gingivitis and periodontitis groups after SRP and were positively correlated with the clinical parameters.

中文翻译：

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健康牙周、牙龈炎和牙周炎患者在根面刮治前后唾液和血清中碱性磷酸酶和酸性磷酸酶水平：临床生化研究

牙周炎通常根据临床参数进行诊断。然而，对唾液和血液中存在的疾病过程的一些独特生物标志物的分析可以进一步帮助估计疾病进展的速度。

目标

本研究试图将健康牙周组织、牙龈炎和慢性牙周炎患者唾液和血清中的碱性磷酸酶 (ALP) 和酸性磷酸酶 (ACP) 水平关联起来。

材料和方法

本研究在 135 名 20 至 55 岁的受试者中进行。将受试者分为三组，即健康组（A组）、牙龈炎组（B组）和慢性牙周炎组（C组）。使用斑块指数（PI）、牙龈指数（GI）和探诊深度（PD）记录临床参数。使用自动分析仪分析唾液和血清的 ALP 和 ACP 水平。所有患者都接受了洁牙和牙根计划（SRP）以及口腔卫生指导。然后在四个星期后召回患者，并在临床检查之前收集血液和唾液样本以估计 ALP 和 ACP 水平。

结果

SRP 后 B 组和 C 组的临床参数显示 PI 和 GI 均显着降低。SRP 后牙周炎组的 PD 和附着水平 (AL) 发生显着变化。SRP 后 B 组和 C 组的平均唾液和血清 ALP 水平在统计学上显着降低。SRP 后 B 组和 C 组的平均血清 ACP 水平在统计学上显着降低，然而，SRP 后唾液 ACP 水平降低仅在 C 组有统计学意义。

结论

SRP后牙龈炎和牙周炎组的血清和唾液ALP和ACP水平显着降低，并且与临床参数呈正相关。