This paper reviews studies that addressed the influence of diet on circadian rhythmicity in mice and, in turn, circadian clock chronodisruption and its role in the development of metabolic disorders. Studies from the past 14 years were selected via a systematic search conducted using the PubMed electronic database. After applying the inclusion and exclusion criteria, 291 studies were selected, of which 13 were chosen using the following inclusion criteria: use of a high-fat diet for mice, evaluation of clock gene expression, and the association between chronodisruption and lipid metabolism disorders. These studies reported changes in animals' biological clock when they developed metabolic disorders by consuming a high-fat diet. It was also evident that some clock gene mutations or deletions triggered metabolic changes. Disturbances of clock gene machinery may play important roles in lipid metabolism and the development of atherosclerotic processes. However, many metabolic processes also affect the function of clock genes and circadian systems. In summary, this review's results may provide new insights into the reciprocal regulation of energy homeostasis and the biological clock.

中文翻译：

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高脂肪饮食会影响生物钟，还是相反？系统评价

本文回顾了饮食对小鼠昼夜节律的影响，进而影响生物钟时间紊乱及其在代谢紊乱发展中的作用的研究。通过使用 PubMed 电子数据库进行的系统搜索，选择了过去 14 年的研究。在应用纳入和排除标准后，选择了 291 项研究，其中使用以下纳入标准选择了 13 项：小鼠使用高脂肪饮食、时钟基因表达的评估以及时间紊乱与脂质代谢紊乱之间的关联。这些研究报告了动物通过食用高脂肪饮食而出现代谢紊乱时生物钟的变化。很明显，一些时钟基因突变或缺失引发了代谢变化。时钟基因机制的干扰可能在脂质代谢和动脉粥样硬化过程的发展中发挥重要作用。然而，许多代谢过程也会影响时钟基因和昼夜节律系统的功能。总之，本综述的结果可能为能量稳态和生物钟的相互调节提供新的见解。