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The relationship between Chlamydia pneumoniae infection and CD4/CD8 ratio, lymphocyte subsets in middle-aged and elderly individuals
Microbial Pathogenesis ( IF 3.3 ) Pub Date : 2020-10-14 , DOI: 10.1016/j.micpath.2020.104541
Xiao-Qing Quan 1 , Chang Xu 2 , Run-Chang Wang 3 , Cun-Tai Zhang 2 , Qing Zhang 4 , Hong-Lian Zhou 2
Affiliation  

Chlamydia pneumoniae (C. pneumoniae) is a common respiratory pathogen associated with many inflammatory diseases. There are few data concerning the lymphocyte subsets in middle-aged and elderly individuals with C. pneumoniae infection. A total of 191 patients were included in this study. The study population was categorized into the middle-aged group (40–64 years old) and the elderly group (65–89 years old). Lymphocyte subsets in peripheral blood were examined with multi-colored flow cytometry. Immunological monitoring included lymphocyte subsets, C. pneumoniae IgG and IgM serology. In the middle-aged group, 69.83% individuals presented IgG positivity, which was associated with the inverted CD4/CD8 ratio. Individuals with C. pneumoniae IgG positivity also presented an increased percentage of CD8+CD28 cells and a decreased CD4/CD8 ratio when compared to weakly-positive individuals. In the elderly group, C. pneumoniae IgG positivity was associated with a significant increase in the percentage of CD3+CD56+CD45+ (NKT) cells. In conclusion, altered lymphocyte homeostasis was shown in middle-aged individuals with C. pneumoniae IgG positivity. The senescent phenotypes of T cells might be associated with C. pneumoniae infection in middle-aged individuals.



中文翻译:

中老年人肺炎衣原体感染与CD4 / CD8比值,淋巴细胞亚群的关系

肺炎衣原体(C. pneumoniae)是一种常见的呼吸道病原体,与许多炎性疾病有关。关于中老年人肺炎衣原体感染的淋巴细胞亚群的数据很少。本研究共纳入191名患者。研究人群分为中年组(40-64岁)和老年组(65-89岁)。用彩色流式细胞仪检查外周血中的淋巴细胞亚群。免疫学监测包括淋巴细胞亚群,肺炎衣原体IgG和IgM血清学。在中年组中,有69.83%的人表现出IgG阳性,这与CD4 / CD8比率倒置有关。肺炎衣原体个体IgG的阳性也呈现CD8的增加的百分比+ CD28 - 细胞,并且当相比较弱阳性个体降低CD4 / CD8比率。在老年组中,肺炎衣原体IgG阳性与CD3 + CD56 + CD45 +(NKT)细胞百分比的显着增加有关。总之,在肺炎衣原体IgG阳性的中年人中显示出淋巴细胞稳态的改变。T细胞的衰老表型可能与中年人的肺炎衣原体感染有关。

更新日期:2020-10-17
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