BACKGROUND Cardiac emboli secondary to atrial fibrillation (AF) commonly cause large vessel occlusions (LVO) that require endovascular thrombectomy (EVT) to restore cerebral circulation. Whether the outcome of patients with AF diagnosed after the index stroke (newAF) differs from that of AF-patients in which AF was known before stroke (kAF) remains unknown. PATIENTS AND METHODS Consecutive LVO patients treated with EVT were recruited and the data was analyzed retrospectively. We compared patients with newAF to those with kAF and those without AF. RESULTS Among 230 patients included, 109 (47%) had AF (86 kAF, 23 newAF). Patients with kAF more often had prior strokes compared with those with newAF (20% vs. 4% p = 0.04) but other parameters did not differ between the groups. Both AF groups were significantly older, more often reached favorable recanalization and less often had favorable outcomes compared to those without AF. On multivariate analyses, timing of AF detection did not influence survival (Odds Ration [OR] 0.89 95% Confidence Interval [CI] 0.28-1.90), chances for favorable recanalization (OR 1.2 95% CI 0.44-3.26) or favorable outcome 1.32 (95% CI 0.57-3.05). CONCLUSIONS Timing of AF diagnosis does not appear to influence outcome in patients with LVO that underwent EVT.

中文翻译：

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房颤检出时间对血管内取栓术后预后的影响

背景继发于心房颤动 (AF) 的心脏栓塞通常会导致大血管闭塞 (LVO)，需要血管内血栓切除术 (EVT) 来恢复脑循环。卒中后确诊的房颤患者（新房颤）的结局是否与卒中前已知房颤（kAF）的房颤患者的结局不同仍然未知。患者和方法 招募接受 EVT 治疗的连续 LVO 患者，并对数据进行回顾性分析。我们将新房颤患者与 kAF 和非房颤患者进行了比较。结果 在纳入的 230 名患者中，109 名（47%）患有 AF（86 kAF，23 名新房颤）。与新AF患者相比，kAF患者更常有既往卒中史（20% vs. 4% p = 0.04），但其他参数在组间没有差异。两个 AF 组都显着变老，与没有 AF 的患者相比，更常达到有利的再通，但不太常有有利的结果。在多变量分析中，AF 检测的时间不影响生存率（比值比 [OR] 0.89 95% 置信区间 [CI] 0.28-1.90）、良好再通的机会（OR 1.2 95% CI 0.44-3.26）或良好结果 1.32（ 95% 置信区间 0.57-3.05)。结论 AF 诊断的时间似乎不会影响接受 EVT 的 LVO 患者的结果。