OBJECTIVE To investigate multiple sclerosis (MS) optical coherence tomography (OCT) cross-sectional correlations with central nervous system (CNS) magnetic resonance imaging (MRI). MATERIAL AND METHODS Peripapillary retinal nerve fiber layer (pRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner (INL) and outer nuclear layer (ONL) of 54 relapsing remitting (RRMS) and 38 progressive (PMS, 9 primary and 29 secondary) patients were measured. With less than 3 months brain parenchymal fraction (BPF), spinal cord (SC), total gray matter (GM) and white matter volumes were calculated. Demographical and clinical data was compared according to the history of optic neuritis (HON). Relationships between OCT and MRI data were assessed using multivariable linear regression models, adjusting for age, gender and disease duration, taking into account HON and disease subtype. RESULTS Cerebellum (p = 0.008), pRNFL (p = 0.001), GCL (p = 0.001) and IPL (p = 0.001) were thinner, while INL was thicker (p = 0.02) if HON. SC correlated better with nasal pRNFL sectors in eyes with HON (all eyes: average pRNFL p = 0.035 η2 = 0.213; N-pRNFL p = 0.04 η2 = 0.36, NI-pRNFL p = 0.0001 η2 = 0.484. RRMS eyes: N-pRNFL p = 0.034 η2 = 0.348; NI-pRNFL p = 0.013 η2 = 0.441), while it correlates with PMB (p = 0.032 η2 = 0.144), GCL (p = 0.03 η2 = 0.147) and IPL (p = 0.028 η2 = 0.151) in eyes without HON regardless of the disease subtype. INL presented no microcystic macular oedema and was inversely associated with BPF (p = 0.029 η2 = 0.363) and cerebellum (p = 0.015 η2 = 0.428) in PMS eyes without HON. CONCLUSIONS OCT data correlates with different CNS compartments, even with no anatomical or functional linkage, serving as useful neurodegeneration and inflammation surrogate marker.

中文翻译：

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超出解剖标志的多发性硬化的磁共振成像和光学相干断层扫描相关性

目的 研究多发性硬化症 (MS) 光学相干断层扫描 (OCT) 横断面与中枢神经系统 (CNS) 磁共振成像 (MRI) 的相关性。材料和方法 54 个复发缓解 (RRMS) 和 38 个进展 (PMS) 的视乳头周围视网膜神经纤维层 (pRNFL)、神经节细胞层 (GCL)、内丛状层 (IPL)、内核层 (INL) 和外核层 (ONL)测量了 9 名初级和 29 名次级）患者。计算不到 3 个月的脑实质分数 (BPF)、脊髓 (SC)、总灰质 (GM) 和白质体积。根据视神经炎 (HON) 的病史比较人口统计学和临床​​数据。使用多变量线性回归模型评估 OCT 和 MRI 数据之间的关系，调整年龄、性别和疾病持续时间，考虑到 HON 和疾病亚型。结果小脑 (p = 0.008)、pRNFL (p = 0.001)、GCL (p = 0.001) 和 IPL (p = 0.001) 较薄，而 INL 较厚 (p = 0.02) 如果 HON。SC 与 HON 眼睛的鼻 pRNFL 扇区相关性更好（所有眼睛：平均 pRNFL p = 0.035 η2 = 0.213；N-pRNFL p = 0.04 η2 = 0.36，NI-pRNFL p = 0.0001 η2 = 0.484.RRMS 眼睛：N-pRNFL p = 0.034 η2 = 0.348；NI-pRNFL p = 0.013 η2 = 0.441)，而它与 PMB (p = 0.032 η2 = 0.144)、GCL (p = 0.03 η2 = 0.142 = 0.148.10p = 0.10p = 0.10.10) 相关) 在没有 HON 的眼睛中，无论疾病亚型如何。在没有 HON 的 PMS 眼中，INL 没有表现出微囊性黄斑水肿，并且与 BPF (p = 0.029 η2 = 0.363) 和小脑 (p = 0.015 η2 = 0.428) 呈负相关。结论 OCT 数据与不同的 CNS 区室相关，