A cross-sectional study on five organized pig farms was conducted to assess the faecal carriage of ESBL and blaNDM carbapenemase-producing E. coli in piglets and pig farmworkers. Faecal samples from piglets (n = 155) and pig farmworkers (n = 21) were processed for isolation and characterization of E. coli. A total of 124 E. coli isolates from piglets and 21 E. coli isolates pig farmworkers were recovered and screening for ESBL production showed that 44.4 % (55/124) of the isolates from piglets and 42.9 % (9/21) of the isolates from farmworkers were ESBL positive. The ESBL positive isolates from piglets and farmworkers harbored blaCTX-M and also co-harbored other beta-lactams, sulphonamide, quinolone and tetracycline resistance genes. Diarrhoeic (50%, 49/98) and crossbred piglets (52.7%, 39/74) harbored a significantly higher number of ESBL producing isolates than non-diarrhoeic (23.1 %, 6/26) and purebred piglets (32%, 16/50) (p < 0.05). Piglets and pig farmworkers harbored nine and two carbapenem-resistant isolates, respectively. Interestingly, two isolates from piglets and one isolate from farmworkers harbored the blaNDM gene. The blaNDM positive E. coli isolated from piglets and farmworkers of the same farm revealed similar antibacterial resistance patterns, resistant genes, sequence (ST-167) and plasmid type (IncX3). In India, carbapenems are not used in food animal treatment, hence carbapenem resistant E. coli in piglets possibly originated from the human contact or common environment and is of public health importance.

在五个有组织的养猪场进行了一项横断面研究，以评估仔猪和养猪场中粪便中ESBL和bla NDM碳青霉烯酶生产大肠杆菌的排泄情况。对仔猪（n = 155）和养猪场工人（n = 21）的粪便样本进行了处理，以分离和鉴定大肠杆菌。总共回收了来自仔猪的124个大肠杆菌分离株和21个猪场工人的大肠杆菌分离株，对ESBL产量的筛选显示，仔猪的分离株为44.4％（55/124），分离株为42.9％（9/21）来自农场工人的结果是ESBL阳性。来自仔猪和农场工人的ESBL阳性分离株带有blaCTX-M以及其他β-内酰胺类，磺酰胺类，喹诺酮类和四环素抗性基因共同感染。腹泻型（50％，49/98）和杂种仔猪（52.7％，39/74）具有比非腹泻型（23.1％，6/26）和纯种仔猪（32％，16 / 50）（p <0.05）。仔猪和养猪场工人分别藏有9株和2株抗碳青霉烯的菌株。有趣的是，有两个来自仔猪的分离株和一个来自农场工人的分离株带有bla NDM基因。所述BLA NDM阳性大肠杆菌从同一农场的仔猪和农场工人分离出的细菌显示出相似的抗菌抗性模式，抗性基因，序列（ST-167）和质粒类型（IncX3）。在印度，未将碳青霉烯类用于食用动物治疗，因此仔猪中的碳青霉烯类抗性大肠杆菌可能源于人类接触或共同环境，具有公共卫生重要性。