The smooth oxidative radical decarboxylation of carboxylic acids with TEMPO and other derivatives as radical scavengers is reported. The key to success was the use of a two-phase solvent system to avoid otherwise predominant side reactions such as the oxidation of TEMPO by persulfate and enabled the selective formation of synthetically useful alkoxyamines. The method does not require transition metals and was successfully used in a new synthetic approach for the antidepressant indatraline.

中文翻译：

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使用双相溶剂体系进行的羧酸的无金属脱羧氨基氧化

据报道，使用TEMPO和其他衍生物作为自由基清除剂可使羧酸平滑氧化自由基脱羧。成功的关键是使用两相溶剂体系，以避免其他主要的副反应，例如过硫酸盐对TEMPO的氧化，并能够选择性地形成合成上有用的烷氧基胺。该方法不需要过渡金属，已成功用于抗抑郁药茚达林的新合成方法中。