N6-methyladenosine (m6A) modification is the most common internal modification of eukaryotic mRNA and is widely involved in many cellular processes, such as RNA transcription, splicing, nuclear transport, degradation, and translation. m6A has been shown to plays important roles in the initiation and progression of various cancers. The altered metabolic programming of cancer cells promotes their cell-autonomous proliferation and survival, leading to an indispensable hallmark of cancers. Accumulating evidence has demonstrated that this epigenetic modification exerts extensive effects on the cancer metabolic network by either directly regulating the expression of metabolic genes or modulating metabolism-associated signaling pathways. In this review, we summarized the regulatory mechanisms and biological functions of m6A and its role in cancer metabolic reprogramming.

中文翻译：

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m6A RNA修饰在癌症代谢重编程中的作用进展


N6-甲基腺苷（m6A）修饰是真核mRNA最常见的内部修饰，广泛参与许多细胞过程，如RNA转录、剪接、核运输、降解和翻译。 m6A 已被证明在各种癌症的发生和进展中发挥重要作用。癌细胞代谢程序的改变促进了它们的细胞自主增殖和存活，这是癌症不可或缺的标志。越来越多的证据表明，这种表观遗传修饰通过直接调节代谢基因的表达或调节代谢相关信号通路对癌症代谢网络产生广泛影响。在这篇综述中，我们总结了 m6A 的调控机制和生物学功能及其在癌症代谢重编程中的作用。