Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing,Lab on a Chip

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Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-10-13 , DOI: 10.1039/d0lc00446d
Yihang Chen ₁ , Shiming Zhang ₂ , Qingyu Cui ₃ , Jiahua Ni ₄ , Xiaochen Wang ₄ , Xuanbing Cheng ₅ , Halima Alem ₆ , Peyton Tebon ₄ , Chun Xu ₄ , Changliang Guo ₃ , Rohollah Nasiri ₇ , Rosalia Moreddu ₈ , Ali K Yetisen ₉ , Samad Ahadian ₄ , Nureddin Ashammakhi ₁₀ , Sam Emaminejad ₁₁ , Vadim Jucaud ₁₂ , Mehmet R Dokmeci ₁₃ , Ali Khademhosseini ₁₄

Affiliation

Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Materials Science and Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA. and Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA.
Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Department of Materials Science and Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Electrical and Computer Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA. and Institut Jean Lamour, Université de Lorraine-CNRS, 54000 Nancy, France and Institut Universitaire de France, France.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA. and Department of Mechanical Engineering, Sharif University of Technology, Tehran, 11365-11155, Iran.
School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK and Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Department of Chemical Engineering, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA. and Department of Radiology, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA. and Department of Electrical and Computer Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA and Department of Radiology, University of California-Los Angeles, Los Angeles, CA 90095, USA.
Center for Minimally Invasive Therapeutics (C-MIT), University of California-Los Angeles, Los Angeles, CA 90095, USA and California NanoSystems Institute, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA 90095, USA. and Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90064, USA and Department of Radiology, University of California-Los Angeles, Los Angeles, CA 90095, USA and Department of Chemical and Biomolecular Engineering, University of California-Los Angeles, Los Angeles, CA 90095, USA.

Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in a dehydrated channel, indicating that the motion of eye-blinking may help tears flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na⁺ sensing capabilities were demonstrated in these microchannels. This work paves the way for the development of microengineered poly(HEMA) hydrogels for various biomedical applications such as eye-care and wearable biosensing.

中文翻译：

用于可穿戴式隐形眼镜生物传感的微工程聚（HEMA）水凝胶

水凝胶中的微通道在实现智能隐形眼镜方面起着至关重要的作用。然而，由于其对常规微加工技术的敏感性，在商业水凝胶隐形眼镜中很少产生微通道。在这里，我们报告了在具有三维（3D）印刷模具的商用隐形眼镜中使用的聚（甲基丙烯酸2-羟乙酯）（poly（HEMA））水凝胶中微通道的制造。我们研究了这些微通道中相应的毛细管流动行为。我们观察到了这些微通道中不同的毛细管流动方式，具体取决于它们的水合程度。特别是，我们发现蠕动压力可以恢复脱水通道中的流动，这表明眨眼的动作可能有助于泪液在含微通道的隐形眼镜中流动。⁺传感能力是在这些微通道证明。这项工作为开发用于各种生物医学应用（如眼部护理和可穿戴生物传感）的微工程聚（HEMA）水凝胶铺平了道路。

更新日期：2020-11-03

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