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Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing
Lab on a Chip ( IF 6.1 ) Pub Date : 2020-10-13 , DOI: 10.1039/d0lc00446d
Yihang Chen 1 , Shiming Zhang 2 , Qingyu Cui 3 , Jiahua Ni 4 , Xiaochen Wang 4 , Xuanbing Cheng 5 , Halima Alem 6 , Peyton Tebon 4 , Chun Xu 4 , Changliang Guo 3 , Rohollah Nasiri 7 , Rosalia Moreddu 8 , Ali K Yetisen 9 , Samad Ahadian 4 , Nureddin Ashammakhi 10 , Sam Emaminejad 11 , Vadim Jucaud 12 , Mehmet R Dokmeci 13 , Ali Khademhosseini 14
Affiliation  

Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in a dehydrated channel, indicating that the motion of eye-blinking may help tears flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. This work paves the way for the development of microengineered poly(HEMA) hydrogels for various biomedical applications such as eye-care and wearable biosensing.

中文翻译:

用于可穿戴式隐形眼镜生物传感的微工程聚(HEMA)水凝胶

水凝胶中的微通道在实现智能隐形眼镜方面起着至关重要的作用。然而,由于其对常规微加工技术的敏感性,在商业水凝胶隐形眼镜中很​​少产生微通道。在这里,我们报告了在具有三维(3D)印刷模具的商用隐形眼镜中使用的聚(甲基丙烯酸2-羟乙酯)(poly(HEMA))水凝胶中微通道的制造。我们研究了这些微通道中相应的毛细管流动行为。我们观察到了这些微通道中不同的毛细管流动方式,具体取决于它们的水合程度。特别是,我们发现蠕动压力可以恢复脱水通道中的流动,这表明眨眼的动作可能有助于泪液在含微通道的隐形眼镜中流动。+传感能力是在这些微通道证明。这项工作为开发用于各种生物医学应用(如眼部护理和可穿戴生物传感)的微工程聚(HEMA)水凝胶铺平了道路。
更新日期:2020-11-03
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