Atopic dermatitis (AD) is a skin disease characterized by chronic inflammatory condition that shows hallmark presentations in terms of sleep disturbances, pruritus, and psychological stress, and an association with increased attention deficit/hyperactivity disorder (ADHD) risk. A number of studies have suggested for the co-occurrence of the two diseased conditions. In terms of global prevalence, AD and ADHD almost exhibit a parallel increment according to epidemiological data. In addition, recent reports indicate AD to show a temporal association with later onset of ADHD. Although several studies suggest for the potential link between AD and ADHD, currently there is no definitive answer to this regard. Furthermore, epidemiological evidence of co-occurrence does not ascertain a pathophysiological link between the two conditions. The pathophysiological basis behind the association of AD and ADHD also remain poorly elucidated. The objective of this review is to present an extensive account of AD and associated comorbidities with a special attention toward ADHD as well as to elaborate on the mechanisms underlying their association. The review can provide healthcare providers with the recent updates on AD-ADHD association and help them while dealing with such patients. In general, AD and ADHD show a positive association in majority of the cross-sectional studies. However, large longitudinal studies are required to draw any conclusion on the temporal nature of such association.

特应性皮炎（AD）是一种以慢性炎症为特征的皮肤疾病，在睡眠障碍，瘙痒和心理压力方面表现出明显的症状，并且与注意力不足/多动症（ADHD）风险增加相关。大量研究表明两种疾病同时存在。就全球患病率而言，根据流行病学数据，AD和ADHD几乎呈平行增长。另外，最近的报道表明AD显示出与ADHD以后发作的时间相关性。尽管有几项研究表明AD和ADHD之间可能存在联系，但目前尚无确切答案。此外，同时发生的流行病学证据不能确定这两种情况之间的病理生理联系。AD和ADHD的关联背后的病理生理基础也仍然不清楚。这篇综述的目的是介绍AD和相关合并症，并特别关注ADHD，并详细阐述其关联的机制。该评论可以为医疗保健提供者提供有关AD-ADHD关联的最新信息，并在与此类患者打交道时为他们提供帮助。通常，AD和ADHD在大多数横断面研究中均显示出正相关关系。但是，需要进行大量的纵向研究才能得出这种关联的时间性质的任何结论。这篇综述的目的是介绍AD和相关合并症，并特别关注ADHD，并详细阐述其关联的机制。该评论可以为医疗保健提供者提供有关AD-ADHD关联的最新信息，并在与此类患者打交道时为他们提供帮助。通常，AD和ADHD在大多数横断面研究中均显示出正相关关系。但是，需要进行大量的纵向研究才能得出这种关联的时间性质的任何结论。这篇综述的目的是介绍AD和相关合并症，并特别关注ADHD，并详细阐述其关联的机制。该评论可以为医疗保健提供者提供有关AD-ADHD关联的最新信息，并在与此类患者打交道时为他们提供帮助。通常，AD和ADHD在大多数横断面研究中均显示出正相关关系。但是，需要进行大量的纵向研究才能得出这种关联的时间性质的任何结论。在大多数横断面研究中，AD和ADHD呈正相关。但是，需要进行大量的纵向研究才能得出这种关联的时间性质的任何结论。在大多数横断面研究中，AD和ADHD呈正相关。但是，需要进行大量的纵向研究才能得出这种关联的时间性质的任何结论。