It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions −592 (C/A), −819 (C/T), and −1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali.

中文翻译：

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简短的交流：西非马里人类 IL10 近端启动子的遗传变异和 HIV-1 感染的易感性

现在人们认识到，要充分了解宿主遗传变异对 HIV-1 感染易感性的作用，必须将调查扩展到非洲人群。我们试图确定IL10的遗传变异是否与马里西非队列中的 HIV-1 感染有关。针对位于IL10的 -592 (C/A)、-819 (C/T) 和 -1082 (G/A) 位置的三种常见单核苷酸多态性 (SNP) 对 HIV 感染和未感染个体进行基因分型发起人。我们发现以前与低 IL-10 表达相关的 ATA 单倍型在队列中是最有代表性的。尽管我们观察到 HIV 感染者与未感染者相比 ATA/ATA 携带频率增加的趋势，但差异无统计学意义。同样，在 HIV 感染组中，单个IL10 SNP 没有显着富集，这表明在来自马里的这个西非队列中， IL10基因变异与 HIV-1 无关。