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Short Communication: Genetic Variation in Human IL10 Proximal Promoter and Susceptibility to HIV-1 Infection in Mali, West Africa
AIDS Research and Human Retroviruses ( IF 1.5 ) Pub Date : 2020-12-31 , DOI: 10.1089/aid.2020.0140
Djeneba Dabitao 1, 2 , Mamadou Dembele 1 , Michael Urbanowski 3 , Bourahima Kone 1 , Mamadou Wague 1 , Nadie Coulibaly 1 , Yeya Dit Sadio Sarro 1 , Bocar Baya 1 , Drissa Goita 1 , Sounkalo Dao 1 , Michael Belson 4 , Sabra L Klein 5 , Chad Achenbach 6, 7 , Jane L Holl 6, 7 , Mahamadou Diakite 1 , Seydou Doumbia 1 , Jay H Bream 5, 8 , William R Bishai 3 , Souleymane Diallo 1 , Robert L Murphy 6, 7
Affiliation  

It is now recognized that to fully understand the role of host genetic variation on susceptibility to HIV-1 infection, investigations must be extended to African populations. We sought to determine if genetic variation in IL10 are associated with HIV-1 infection in a West African cohort in Mali. HIV-infected and -uninfected individuals were genotyped for three common single nucleotide polymorphisms (SNPs) located at positions −592 (C/A), −819 (C/T), and −1082 (G/A) of the IL10 promoter. We found that the ATA haplotype, which has been previously associated with low IL-10 expression, was the most represented in the cohort. Although we observed a trend toward an increased frequency of ATA/ATA carriage in HIV-infected compared with -uninfected individuals, the difference was not statistically significant. Similarly, individual IL10 SNPs were not significantly enriched in the HIV-infected group, suggesting that IL10 genetic variants are not associated with HIV-1 in this West African cohort from Mali.

中文翻译:

简短的交流:西非马里人类 IL10 近端启动子的遗传变异和 HIV-1 感染的易感性

现在人们认识到,要充分了解宿主遗传变异对 HIV-1 感染易感性的作用,必须将调查扩展到非洲人群。我们试图确定IL10的遗传变异是否与马里西非队列中的 HIV-1 感染有关。针对位于IL10的 -592 (C/A)、-819 (C/T) 和 -1082 (G/A) 位置的三种常见单核苷酸多态性 (SNP) 对 HIV 感染和未感染个体进行基因分型发起人。我们发现以前与低 IL-10 表达相关的 ATA 单倍型在队列中是最有代表性的。尽管我们观察到 HIV 感染者与未感染者相比 ATA/ATA 携带频率增加的趋势,但差异无统计学意义。同样,在 HIV 感染组中,单个IL10 SNP 没有显着富集,这表明在来自马里的这个西非队列中, IL10基因变异与 HIV-1 无关。
更新日期:2021-01-07
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