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A New Strategy: Distinguishable Multi-substance Detection, Multiple Pathway Tracing Based on a New Site Constructed by the Reaction Process and Its Tumor Targeting
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-10-13 , DOI: 10.1021/jacs.0c10210 Yongfei Huang 1 , Yongbin Zhang 2 , Fangjun Huo 2 , Jianbin Chao 2 , Fangqin Cheng 3 , Caixia Yin 1
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2020-10-13 , DOI: 10.1021/jacs.0c10210 Yongfei Huang 1 , Yongbin Zhang 2 , Fangjun Huo 2 , Jianbin Chao 2 , Fangqin Cheng 3 , Caixia Yin 1
Affiliation
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In recent years, it has become a trend to employ organic molecular fluorescent probes with multireaction sites for the distinguishable detection and biological imaging of similar substances. However, the introduction of multireaction sites brought great challenges to organic synthesis, and at the same time, often destroyed the conjugated structure of the molecules, leading to an unsatisfactory fluorescence emission wavelength not conducive to practical application. As the eternal theme of life, metabolism goes on all the time. Metabolism is a series of ordered chemical reactions that occurs in the organism to maintain life. Chemical reactions in metabolism can be summarized as metabolic pathways. Simultaneous monitoring of different metabolic pathways of the same substance poses a lofty challenge to the probe. Here, we developed a new strategy: to construct new sites through the preliminary reactions between probes and some targets, which can be used to further distinguish among targets or detect their metabolites, so as to realize the simultaneous visualization tracer of multiple metabolic pathways. By intravenous injection, it revealed that the probe containing benzopyrylium ion can target tumors efficiently, and thiols are highly expressed in tumors compared to other tissues (heart, lung, kidney, liver, etc.). The consumption of thiols by the probe could not prevent tumor growth, suggesting that the tumor cure was not correlated with thiol concentration. The construction of new sites in the reaction process is a novel idea in the pursuit of multiple reaction sites, which will provide more effective tools for solving practical problems.
中文翻译：
新策略：基于反应过程构建的新位点及其肿瘤靶向的可区分多物质检测、多通路追踪
近年来，采用具有多反应位点的有机分子荧光探针对相似物质进行可区分检测和生物成像已成为一种趋势。然而，多反应位点的引入给有机合成带来了巨大挑战，同时往往破坏了分子的共轭结构，导致荧光发射波长不理想，不利于实际应用。作为生命永恒的主题，新陈代谢一直在进行。代谢是在生物体内发生的一系列有序化学反应，以维持生命。代谢中的化学反应可以概括为代谢途径。同时监测同一物质的不同代谢途径对探针提出了很高的挑战。在这里，我们制定了一个新策略：通过探针与某些靶标之间的初步反应构建新的位点，用于进一步区分靶标或检测其代谢物，从而实现多种代谢途径的同时可视化示踪。通过静脉注射，揭示了含有苯并吡喃离子的探针可以有效靶向肿瘤，与其他组织（心、肺、肾、肝等）相比，硫醇在肿瘤中高表达。探针消耗的硫醇不能阻止肿瘤生长，表明肿瘤治愈与硫醇浓度无关。在反应过程中构建新的位点是追求多反应位点的一个新思路，将为解决实际问题提供更有效的工具。
更新日期：2020-10-13
中文翻译：
新策略：基于反应过程构建的新位点及其肿瘤靶向的可区分多物质检测、多通路追踪
近年来，采用具有多反应位点的有机分子荧光探针对相似物质进行可区分检测和生物成像已成为一种趋势。然而，多反应位点的引入给有机合成带来了巨大挑战，同时往往破坏了分子的共轭结构，导致荧光发射波长不理想，不利于实际应用。作为生命永恒的主题，新陈代谢一直在进行。代谢是在生物体内发生的一系列有序化学反应，以维持生命。代谢中的化学反应可以概括为代谢途径。同时监测同一物质的不同代谢途径对探针提出了很高的挑战。在这里，我们制定了一个新策略：通过探针与某些靶标之间的初步反应构建新的位点，用于进一步区分靶标或检测其代谢物，从而实现多种代谢途径的同时可视化示踪。通过静脉注射，揭示了含有苯并吡喃离子的探针可以有效靶向肿瘤，与其他组织（心、肺、肾、肝等）相比，硫醇在肿瘤中高表达。探针消耗的硫醇不能阻止肿瘤生长，表明肿瘤治愈与硫醇浓度无关。在反应过程中构建新的位点是追求多反应位点的一个新思路，将为解决实际问题提供更有效的工具。
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