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Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
npj Digital Medicine ( IF 12.4 ) Pub Date : 2020-10-13 , DOI: 10.1038/s41746-020-00335-x
Gabriela M Stegmann 1, 2 , Shira Hahn 1, 2 , Julie Liss 1, 2 , Jeremy Shefner 3 , Seward Rutkove 4 , Kerisa Shelton 3 , Cayla Jessica Duncan 3 , Visar Berisha 1, 2
Affiliation  

Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a cohort of N = 65 ALS patients who provided regular speech samples for 3–9 months, we demonstrated that it is possible to remotely detect early speech changes and track speech progression in ALS via automated algorithmic assessment of speech collected digitally.



中文翻译:


通过频繁和远程语音分析早期检测和跟踪 ALS 中的延髓变化



肌萎缩侧索硬化症 (ALS) 的延髓退化是一种破坏性特征,会损害患者的沟通能力,并与较短的生存期相关。现有的评估延髓功能的临床仪器对早期变化缺乏敏感性。在本文中,我们使用一组N = 65 名 ALS 患者提供 3-9 个月的定期语音样本,证明可以通过对数字收集的语音进行自动算法评估来远程检测早期语音变化并跟踪 ALS 的语音进展。

更新日期:2020-10-13
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