Due to the population explosion of the 21st century, nearly one billion people are over 64 years of age and bone fracture is one of the most frequent problems facing both sexes because of osteoporosis. However, difficulty in enhancing bone regeneration to repair bone fracture poses challenges and thus, a two-dimensional monolayer material (i.e. tungsten disulfide (WS₂)) could be one of the candidates offering a possible solution to the problem. Here, we prepare high-quality monolayer WS₂ thin sheets in a large quantity with the assistance of extracted chlorophyll molecules, the natural pigment used in photosynthesis, via a liquid-phase exfoliation method. Then, the exfoliated WS₂ sheets were mixed with polycaprolactone (PCL)/calcium silicate (CS) to form a biocompatible WS₂-based composite. The in vivo experiments show that the bone regeneration of the WS₂-based composite was 120% superior to commercially available mineral trioxide aggregate (MTA) bone cement. Moreover, the mechanical properties of the WS₂-based composite exhibited ~300% enhancement over PCL/CS, which is one of the most commonly used bone regeneration materials. Our findings highlight the prospects for the composite of WS₂ towards the improvement of bone regeneration applications.

由于21世纪的人口激增，将近10亿人的64岁以上年龄段，由于骨质疏松症，骨折是两性面对的最常见问题之一。然而，增强骨骼再生以修复骨折的难度提出了挑战，因此，二维单层材料（即二硫化钨（WS ₂））可能是解决该问题的候选材料之一。在这里，我们通过液相剥离法，借助提取的叶绿素分子（光合作用的天然色素），大量制备了高质量的单层WS ₂薄板。然后，去角质的WS ₂将板与聚己内酯（PCL）/硅酸钙（CS）混合以形成基于生物相容性WS ₂的复合材料。体内实验表明，基于WS ₂的复合材料的骨再生性能比市售的三氧化二矿物骨料（MTA）骨水泥优越120％。此外，基于WS ₂的复合材料的机械性能比PCL / CS增强了约300％，后者是最常用的骨再生材料之一。我们的发现突出了WS ₂复合材料在改善骨再生应用方面的前景。