Abstract Artemisia vulgaris hydrogel (AVH) was acetylated (AAVH) and characterized by FTIR, CP/MAS 13C-NMR spectroscopic techniques and thermogravimetric analysis. Flynn–Waal–Ozawa model was used to investigate thermal degradation kinetics. Energy of activation (Ea) values of first and major thermal degradation steps were found to be 128.14 and 116.85 kJmol−1 for AVH and AAVH, respectively. Thermodynamic triplet, order of degradation reaction, integral procedural decomposition temperature (IPDT) and comprehensive index of intrinsic thermal stability (ITS) were also taken into account. In vitro caffeine release from AVH-based matrix tablets indicates potential of AVH for the development of oral delivery systems for sustained drug release.

中文翻译：

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艾蒿水凝胶及其醋酸盐的等转化热分析比较；持续给药的潜在基质

摘要 青蒿水凝胶(AVH) 被乙酰化(AAVH)，并通过FTIR、CP/MAS 13C-NMR 光谱技术和热重分析表征。Flynn-Waal-Ozawa 模型用于研究热降解动力学。发现第一和主要热降解步骤的活化能 (Ea) 值对于 AVH 和 AAVH 分别为 128.14 和 116.85 kJmol-1。还考虑了热力学三重态、降解反应顺序、积分程序分解温度（IPDT）和内在热稳定性综合指数（ITS）。基于 AVH 的基质片剂的体外咖啡因释放表明 AVH 具有开发用于持续药物释放的口服给药系统的潜力。