Abstract

An efficient and rapid one-pot multicomponent synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones through condensation of aldehyde, malononitrile and phthalhydrazide catalyzed by agro-waste solvent catalyst-derived water extract of mango peel ash (WEMPA) under microwave irradiation is described. Further, the catalyst is prepared from agricultural waste and characterized for elemental composition by different techniques such as SEM-EDX, XRD and flame photometry. This green synthetic approach offers various advantages such as inexpensive, abundantly available source, shorter reaction time (6–8 min), good-to-excellent yield (83%–89%), simple workup and a sustainable alternative method to the existing protocols. All the synthesized compounds (4a–l) was confirmed by FT-IR, ¹H-NMR, ¹³C-NMR and LC-MS.

摘要

农业废弃物溶剂催化剂芒果皮水提物催化醛、丙二腈和邻苯二甲酰肼缩合高效快速一锅法合成 1 H-吡唑并[1,2-b]酞嗪-5,10-二酮描述了微波辐射下的灰分（WEMPA）。此外，该催化剂由农业废弃物制备，并通过不同的技术（如 SEM-EDX、XRD 和火焰光度法）表征元素组成。这种绿色合成方法具有多种优势，例如价格低廉、来源丰富、反应时间更短（6-8 分钟）、产率从好到极好（83%-89%）、后处理简单以及现有方案的可持续替代方法. 所有合成的化合物 ( 4a-l ) 均经 FT-IR 确认，¹ H-NMR、¹³ C-NMR和LC-MS。