Thyroid hormones in diabetes, cancer, and aging,Aging Cell

当前位置： X-MOL 学术 › Aging Cell › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Thyroid hormones in diabetes, cancer, and aging
Aging Cell ( IF 8.0 ) Pub Date : 2020-10-13 , DOI: 10.1111/acel.13260
Benoit R Gauthier _{1,

2} , Alejandro Sola-García ₁ , María Ángeles Cáliz-Molina ₁ , Petra Isabel Lorenzo ₁ , Nadia Cobo-Vuilleumier ₁ , Vivian Capilla-González ₁ , Alejandro Martin-Montalvo ₁

Affiliation

Thyroid function is central in the control of physiological and pathophysiological processes. Studies in animal models and human research have determined that thyroid hormones modulate cellular processes relevant for aging and for the majority of age‐related diseases. While several studies have associated mild reductions on thyroid hormone function with exceptional longevity in animals and humans, alterations in thyroid hormones are serious medical conditions associated with unhealthy aging and premature death. Moreover, both hyperthyroidism and hypothyroidism have been associated with the development of certain types of diabetes and cancers, indicating a great complexity of the molecular mechanisms controlled by thyroid hormones. In this review, we describe the latest findings in thyroid hormone research in the field of aging, diabetes, and cancer, with a special focus on hepatocellular carcinomas. While aging studies indicate that the direct modulation of thyroid hormones is not a viable strategy to promote healthy aging or longevity and the development of thyromimetics is challenging due to inefficacy and potential toxicity, we argue that interventions based on the use of modulators of thyroid hormone function might provide therapeutic benefit in certain types of diabetes and cancers.

中文翻译：

糖尿病、癌症和衰老中的甲状腺激素

甲状腺功能是控制生理和病理生理过程的核心。动物模型研究和人类研究表明，甲状腺激素调节与衰老和大多数与年龄相关的疾病相关的细胞过程。虽然几项研究将甲状腺激素功能的轻度降低与动物和人类的超长寿命联系起来，但甲状腺激素的改变是与不健康衰老和过早死亡相关的严重医学状况。此外，甲状腺功能亢进症和甲状腺功能减退症都与某些类型的糖尿病和癌症的发展有关，这表明甲状腺激素控制的分子机制非常复杂。在这篇综述中，我们描述了甲状腺激素研究在衰老、糖尿病、和癌症，特别关注肝细胞癌。虽然衰老研究表明直接调节甲状腺激素不是促进健康衰老或长寿的可行策略，并且由于低效和潜在毒性，拟甲状腺素的开发具有挑战性，但我们认为基于使用甲状腺激素功能调节剂的干预措施可能对某些类型的糖尿病和癌症提供治疗益处。

更新日期：2020-11-23

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11