Iron Catalyzed Isomerization of α‐Alkyl Styrenes to Access Trisubstituted Alkenes,Chinese Journal of Chemistry

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Iron Catalyzed Isomerization of α‐Alkyl Styrenes to Access Trisubstituted Alkenes
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-10-13 , DOI: 10.1002/cjoc.202000492
Songgen Xu ₁ , Guixia Liu ₁ , Zheng Huang _{1,

2,

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Affiliation

Stereoselective isomerization of α‐alkyl styrenes is accomplished using a new iron catalyst supported by phosphine‐pyridine‐oxazoline (PPO) ligand. The protocol provides an atom‐efficient and operationally simple approach to trisubstituted alkenes in high yields with excellent regio‐ and stereoselectivities under mild conditions. The results of deuterium‐labelling and radical trap experiments are consistent with an iron‐hydride pathway involving reversible alkene insertion and β‐H elimination.

中文翻译：

铁催化α-烷基苯乙烯的异构化反应以得到三取代的烯烃

α-烷基苯乙烯的立体选择性异构化是通过使用膦-吡啶-恶唑啉（PPO）配体支持的新型铁催化剂完成的。该协议提供了一种原子效率高且操作简单的方法，可在温和条件下以高收率和出色的区域选择性和立体选择性对三取代烯烃进行生产。氘标记和自由基陷阱实验的结果与涉及可逆烯烃插入和β-H消除的铁氢化物途径一致。

更新日期：2020-10-13

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