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Rhodiola crenulata protects against Alzheimer's disease in rats: A brain lipidomics study by Fourier‐transform ion cyclotron resonance mass spectrometry coupled with high‐performance reversed‐phase liquid chromatography and hydrophilic interaction liquid chromatography
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-10-12 , DOI: 10.1002/rcm.8969
Wei Sun 1 , Chun Liu 2 , Yanan Wang 3 , Xing Zhou 4 , Wenwen Sui 5 , Yu Zhang 3 , Qingyu Zhang 3 , Jing Han 3 , Xintong Li 3 , Fei Han 3
Affiliation  

Alzheimer's disease (AD) is a chronic, severe, progressive neurodegenerative disorder associated with cognitive and memory impairment that ultimately causes death. Most approved drugs can only alleviate some of the symptoms of AD, but no interventions have been found that reverse the underlying disease mechanisms. Rhodiola crenulata extract (RCE) has been reported to alleviate AD symptoms in rats. However, its underlying mechanism of action is still unclear.

中文翻译:

红景天预防大鼠阿尔茨海默病:傅里叶变换离子回旋共振质谱结合高效反相液相色谱和亲水相互作用液相色谱的脑脂质组学研究

阿尔茨海默病 (AD) 是一种慢性、严重、进行性神经退行性疾病,与认知和记忆障碍相关,最终导致死亡。大多数获批的药物只能缓解 AD 的部分症状,但尚未发现逆转潜在疾病机制的干预措施。据报道,红景天提取物 (RCE) 可减轻大鼠的 AD 症状。然而,其潜在的作用机制仍不清楚。
更新日期:2020-11-18
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