Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus,Human Brain Mapping

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Alterations of brain activity and functional connectivity in transition from acute to chronic tinnitus
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-10-13 , DOI: 10.1002/hbm.25238
Liping Lan _{1,

2} , Jiahong Li _{1,

2} , Yanhong Chen _{1,

2} , Wan Chen ₃ , Wenrui Li _{1,

2} , Fei Zhao _{4,

5} , Guisheng Chen _{1,

2} , Jiahao Liu _{1,

2} , Yuchen Chen ₆ , Yuanqing Li ₇ , Chang-Dong Wang ₈ , Yiqing Zheng _{1,

2} , Yuexin Cai _{1,

2}

Affiliation

The objective of this study was to investigate alterations to brain activity and functional connectivity in patients with tinnitus, exploring neural features in the transition from acute to chronic phantom perception. Twenty‐four patients with acute tinnitus, 23 patients with chronic tinnitus, and 32 healthy controls were recruited. High‐density electroencephalography (EEG) was used to explore changes in brain areas and functional connectivity in different groups. When compared with healthy subjects, acute tinnitus patients had a significant reduction in superior frontal cortex activity across all frequency bands, whereas chronic tinnitus patients had a significant reduction in the superior frontal cortex at beta 3 and gamma frequency bands as well as a significant increase in the inferior frontal cortex at delta‐band and superior temporal cortex at alpha 1 frequency band. When compared to the chronic tinnitus group, the acute tinnitus group activity was significantly increased in the middle frontal and parietal gyrus at the gamma‐band. Functional connectivity analysis showed that the chronic tinnitus group had increased connections between the parahippocampus gyrus, posterior cingulate cortex, and precuneus when compared with the healthy group. Alterations of local brain activity and connections between the parahippocampus gyrus and other nonauditory areas appeared in the transition from acute to chronic tinnitus. This indicates that the appearance and development of tinnitus is a dynamic process involving aberrant local neural activity and abnormal connectivity in multifunctional brain networks.

中文翻译：

从急性耳鸣到慢性耳鸣的转变过程中大脑活动和功能连接的变化

本研究的目的是调查耳鸣患者大脑活动和功能连接的变化，探索从急性幻觉到慢性幻觉感知过渡的神经特征。招募了 24 名急性耳鸣患者、23 名慢性耳鸣患者和 32 名健康对照者。高密度脑电图（EEG）用于探索不同组的大脑区域和功能连接的变化。与健康受试者相比，急性耳鸣患者在所有频段的上额叶皮质活动显着降低，而慢性耳鸣患者的上额叶皮层在 β 3 和 γ 频带显着减少，而下额叶皮层在 δ 频带和上颞叶皮质在 α1 频带显着增加。与慢性耳鸣组相比，急性耳鸣组在伽马波段的额中回和顶叶回活动显着增加。功能连接分析显示，与健康组相比，慢性耳鸣组海马旁回、后扣带回和楔前叶之间的连接增加。局部大脑活动的改变以及海马旁回和其他非听觉区域之间的连接出现在从急性耳鸣到慢性耳鸣的转变中。

更新日期：2020-10-13

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