B-lymphoblastic leukemia (B-ALL) is the most common childhood malignancy, and its diagnosis requires immunophenotypically demonstrating blast B cell lineage differentiation. Expression of myeloperoxidase (MPO) in B-ALL is well-described and it has been recognized that a diagnosis of mixed phenotype acute leukemia should be made cautiously if MPO expression is the sole myeloid feature in these cases. We sought to determine whether MPO expression in pediatric B-ALL was associated with differences in laboratory, immunophenotypic, or clinical features.

中文翻译：

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与儿童 B 淋巴细胞白血病中髓过氧化物酶表达相关的临床和实验室特征

B 淋巴细胞白血病 (B-ALL) 是最常见的儿童恶性肿瘤，其诊断需要免疫表型证明 B 细胞谱系分化。B-ALL 中髓过氧化物酶 (MPO) 的表达已得到充分描述，并且已经认识到，如果 MPO 表达是这些病例中唯一的髓样特征，则应谨慎诊断混合表型急性白血病。我们试图确定儿科 B-ALL 中 MPO 的表达是否与实验室、免疫表型或临床特征的差异有关。