Unraveling the molecular interactions governing the first contact between parasite and host tissues is of paramount importance to the development of effective control strategies against parasites. In fasciolosis, a foodborne trematodiasis caused mainly by Fasciola hepatica, these early interactions occur between the juvenile worm and the host intestinal wall a few hours after ingestion of metacercariae, the infectious stage of the parasite. However, research on these early events is still scarce and the majority of studies have focused on the adult worm. Here, we review current knowledge on the biology and biochemistry of F. hepatica juveniles and their molecular relationships with the host tissues and identify the research needs and gaps to be covered in the future.

阐明控制寄生虫与宿主组织之间首次接触的分子相互作用对于开发有效的控制寄生虫控制策略至关重要。在fasciolosis（一种主要由肝Fasciola肝炎引起的食源性皮肤性皮肤病）中，这些早期相互作用发生在食入meta虫（感染的寄生虫）的几个小时后，在幼虫和宿主肠壁之间发生。但是，对这些早期事件的研究仍然很少，并且大多数研究都集中在成虫上。在这里，我们回顾了当前有关肝炎小球藻幼虫的生物学和生物化学及其与宿主组织的分子关系的知识，并确定了未来需要研究的领域和差距。