The multi-lineage differentiation potential is one of the prominent mechanisms through which stem cells can repair damaged tissues. The regenerative potential of stem cells is manifestation of several changes at the structural and molecular levels in stem cells that are regulated through intricate mitochondrial-nuclear interactions maintained by Ca2+ ion signaling. Despite the exhilarating evidences strengthening the versatile and indispensible role of Ca2+ in regulating mitochondrial-nuclear interactions, the extensive details of signaling mechanisms remains largely unexplored. In this review we have discussed the effect of Ca2+ ion mediated mitochondrial-nuclear interactions participating in stem plasticity and its regenerative potential.

中文翻译：

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通过 Ca2+ 介导的线粒体核串扰对干细胞可塑性和再生潜能进行调节

多谱系分化潜能是干细胞修复受损组织的重要机制之一。干细胞的再生潜力是干细胞结构和分子水平上的几种变化的表现，这些变化通过由 Ca2+ 离子信号维持的复杂线粒体-核相互作用进行调节。尽管令人振奋的证据加强了 Ca2+ 在调节线粒体 - 核相互作用中的多功能和不可或缺的作用，但信号机制的广泛细节在很大程度上仍未得到探索。在这篇综述中，我们讨论了 Ca2+ 离子介导的线粒体核相互作用对茎可塑性及其再生潜力的影响。