Abstract This study investigated the significance of process parameters in the rapid expansion of supercritical solutions (RESS) for microparticle production of ipriflavone by using a two-level (2k) factorial design. Four process parameters, namely the extraction temperature (A), extraction pressure (B), pre-expansion temperature (C), and postexpansion temperature (D), of RESS were studied. The mean particle size data and results of analysis of variance revealed that the effect of C and the cross-interaction effect of AD and BD were significant in the process. The trends of these significant effects were evaluated through crystallization kinetics. After the RESS was performed, ipriflavone exhibited a considerably reduced mean size of 3 μm and a flake-like habit. In addition, differential scanning calorimetry and powder X-ray diffraction revealed that the crystal form of ipriflavone remained unchanged after RESS.

中文翻译：

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超临界溶液快速膨胀法生产异黄酮微粒的两水平析因设计工艺参数研究

摘要 本研究通过使用两水平 (2k) 因子设计，研究了工艺参数在超临界溶液 (RESS) 快速膨胀以生产异黄酮微粒中的重要性。研究了RESS的四个工艺参数，即萃取温度(A)、萃取压力(B)、预膨胀温度(C)和后膨胀温度(D)。平均粒径数据和方差分析结果表明，C的影响以及AD和BD的交叉相互作用在该过程中是显着的。通过结晶动力学评估这些显着影响的趋势。在进行 RESS 后，ipriflavone 表现出显着减小的 3 μm 平均尺寸和薄片状习性。此外，