Effective methods to treat bacterial infections are highly desired as the abuse of antibiotics has caused multidrug-resistant. Polysaccharide hydrogel-based drug delivery systems possessing inherent large surface area and biocompatibility attributes provide a promising strategy for effective use of antibiotics. Here, we presented an effective method for fabricating macroporous polysaccharide hydrogels composed of dextran (DP) and polydopamine (PDA) for controlled release of antibiotics. The physicochemical properties of resulting DP hydrogels were systematically evaluated by measuring their swelling, viscoelasticity, morphology, sorption and thermal stability, and we could control these properties through simply changing the PDA concentration in a pre-gel solution. The low cytotoxicity of DP hydrogels was demonstrated through a co-culture with mouse fibroblast cells. Moreover, in vitro/vivo antibacterial properties of the drug-loading DP hydrogels were evaluated, and they exhibited good antibacterial and healing performances. We believe that the proposed strategy for facilitation and optimization of polysaccharide hydrogels could offer more hydrogel dressings when choosing suitable carriers for sustained release of antibiotics.

由于抗生素的滥用已引起多药耐药性，因此迫切需要有效的方法来治疗细菌感染。具有固有的大表面积和生物相容性属性的基于多糖水凝胶的药物递送系统为有效使用抗生素提供了一种有希望的策略。在这里，我们提出了一种有效的方法来制造由葡聚糖（DP）和聚多巴胺（PDA）组成的大孔多糖水凝胶，以控制抗生素的释放。通过测量它们的膨胀，粘弹性，形态，吸附和热稳定性，系统地评估了所得DP水凝胶的理化性质，我们可以通过简单地改变预凝胶溶液中的PDA浓度来控制这些性质。通过与小鼠成纤维细胞共培养证明了DP水凝胶的低细胞毒性。此外，评价了载药DP水凝胶的体外/体内抗菌性能，它们显示出良好的抗菌和愈合性能。我们认为，抗生素缓释选择合适的载体时，所提出的战略便利和糖水凝胶的优化可以提供更多的水凝胶敷料。