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Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes
Biosystems ( IF 2.0 ) Pub Date : 2020-10-13 , DOI: 10.1016/j.biosystems.2020.104273
Sergey V. Petoukhov

The author's method of oligomer sums for analysis of oligomer compositions of eukaryotic and prokaryotic genomes is described. The use of this method revealed the existence of general rules for the cooperative oligomeric organization of a wide list of genomes. These rules are called hyperbolic because they are associated with hyperbolic sequences including the harmonic progression 1, 1/2, 1/3, .., 1/n. These rules are demonstrated by examples of quantitative analysis of many genomes from the human genome to the genomes of archaea and bacteria. The hyperbolic (harmonic) rules, speaking about the existence of algebraic invariants in full genomic sequences, are considered as candidates for the role of universal rules for the cooperative organization of genomes. The results concerns additionally the problem of the origin of life. The described phenomenological results were obtained as consequences of the previously published author's quantum-information model of long DNA sequences. The oligomer sums method was also applied to the analysis of long genes and viruses including the COVID-19 virus; this revealed, in characteristics of many of them, the phenomenon of such rhythmically repeating deviations from model hyperbolic sequences, which are associated with DNA triplets. In addition, an application of the oligomer sums method is shown to the analysis of amino acid sequences in long proteins like the protein Titin. The topics of the algebraic harmony in living bodies and of the quantum-information approach in biology are discussed.



中文翻译:

真核和原核基因组合作组织的双曲规则

描述了作者的寡聚物总和方法,用于分析真核和原核基因组的寡聚物组成。这种方法的使用揭示了存在广泛的基因组合作寡聚组织的一般规则。这些规则称为双曲线,因为它们与包括谐波级数1、1 / 2、1 / 3,..,1 / n的双曲线序列相关联。从人类基因组到古细菌和细菌的基因组对许多基因组进行定量分析的实例证明了这些规则。谈到完整基因组序列中存在代数不变量的双曲(谐波)规则被认为是通用规则对基因组合作组织作用的候选者。结果还涉及生命起源问题。所描述的现象学结果是作为先前发表的作者的长DNA序列的量子信息模型的结果而获得的。寡聚和法还用于分析长基因和病毒,包括COVID-19病毒;这揭示了许多模型的特征,即从模型双曲序列有节奏地重复偏离的现象,与DNA三胞胎相关。另外,显示了低聚物总和法在分析长蛋白(如蛋白)中氨基酸序列中的应用。讨论了生物中的代数和谐和生物学中的量子信息方法的主题。

更新日期:2020-10-30
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