Background

Findings regarding chemotherapy-induced grey matter abnormalities are heterogeneous, and no meta-analysis has quantitatively assessed brain structural alterations in cancer survivors treated with chemotherapy.

Purpose

To investigate the grey matter abnormalities in non-CNS (central nervous system) cancer survivors treated with chemotherapy using Anisotropic Effect Size Signed Differential Mapping (AES-SDM) software.

Method

We identified studies published up to Sep 2018 that compared grey matter in non-CNS cancer survivors treated with chemotherapy (CT+, 10 data sets including 433 individuals) and cancer survivors not treated with chemotherapy (CT-, 7 data sets including 210 individuals) or healthy controls (HC, 3 data sets including 407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise.

Results

Compared with both CT- and HC, the CT + groups exhibited a reduced grey matter volume (GMV), mainly in the prefrontal and anterior cingulate cortex (ACC) and right fusiform gyrus (FG). A smaller GMV in the FG and prefrontal cortex were found in the CT + compared with the CT-groups and in the CT + groups with impaired cognition. GMV in two areas was positively associated with the time since chemotherapy.

Conclusions

The present results suggest that non-CNS cancer survivors treated with chemotherapy exhibit grey matter abnormalities in the brain, especially in the prefrontal and ACC cortex. Grey matter volume changes after chemotherapy may contribute to cognitive impairments in cancer survivors that can be observed after chemotherapy.

中文翻译：

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癌症幸存者中化疗引起的灰质异常：体素神经影像学荟萃分析

背景

关于化疗引起的灰质异常的发现是异质的，并且没有荟萃分析定量评估接受化疗的癌症幸存者的大脑结构改变。

目的

使用各向异性效应大小符号微分映射 (AES-SDM) 软件研究接受化疗的非 CNS（中枢神经系统）癌症幸存者的灰质异常。

方法

我们确定了截至 2018 年 9 月发表的研究，这些研究比较了接受化疗的非 CNS 癌症幸存者（CT+，10 个数据集，包括 433 个个体）和未接受化疗的癌症幸存者（CT-，7 个数据集，包括 210 个个体）或使用全脑 VBM 的健康对照（HC，3 个数据集，包括 407 个人）。我们使用了来自研究的统计图，如果可用，则报告峰值坐标。

结果

与 CT- 和 HC 相比，CT + 组表现出减少的灰质体积 (GMV)，主要在前额叶和前扣带皮层 (ACC) 和右侧梭状回 (FG)。与 CT 组和认知受损的 CT + 组相比，在 CT + 中发现 FG 和前额叶皮层中的 GMV 较小。两个区域的 GMV 与化疗后的时间呈正相关。

结论

目前的结果表明，接受化疗的非中枢神经系统癌症幸存者表现出大脑灰质异常，尤其是前额叶和 ACC 皮层。化疗后灰质体积的变化可能会导致癌症幸存者的认知障碍，这在化疗后可以观察到。