By employing a mixed-ligand strategy, two new coordination polymers with the chemical formulae [Co(4-bptzh)(1,3-BDC)] (1) and [Zn(4-bptzp)(1,3-BDC)]n (2) are hydrothermally synthesized using two flexible bis(pyridyl-tetrazole) ligands (4-bptzh = 1,4-bis(5-(4-pyridyl)tetrazolyl)hexane, 4-bptzp = 1,4-bis(5-(4-pyridyl)tetrazolyl)propane) and 1,3-benzenedicarboxylic acid (1,3-H2BDC). Both complexes are characterized by single crystal X-ray diffraction along with the elemental analysis. Furthermore, the inhibitory effect of compounds 1 and 2 against CNE-1 nasopharyngeal cancer cells are evaluated in vitro. Firstly, the antiproliferation activity of compounds 1 and 2 against cancer cells is assessed by the CCK-8 assay. Then, the cancer cell apoptosis is measured with the Annexin V-FITC/PI apoptosis assay by flow cytometry.

中文翻译：

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两种 Co(II) 和 Zn(II) 配位聚合物：结构表征和抗鼻咽癌的抗癌活性

通过采用混合配体策略，两种新的配位聚合物具有化学式 [Co(4-bptzh)(1,3-BDC)] (1) 和 [Zn(4-bptzp)(1,3-BDC)] n (2) 是使用两个灵活的双（吡啶基-四唑）配体（4-bptzh = 1,4-双（5-（4-吡啶基）四唑）己烷，4-bptzp = 1,4-双（5 -(4-吡啶基)四唑基)丙烷)和 1,3-苯二甲酸 (1,3-H2BDC)。两种配合物均通过单晶 X 射线衍射和元素分析进行​​表征。此外，在体外评估了化合物1和2对CNE-1鼻咽癌细胞的抑制作用。首先，通过CCK-8测定评估化合物1和2对癌细胞的抗增殖活性。然后，通过流式细胞术用 Annexin V-FITC/PI 凋亡测定法测量癌细胞凋亡。