The ability to design polymers with a controlled degradation profile and mechanical and processing properties has opened opportunities for developing novel polymer-based drug delivery devices, sutures, implants, etc. While numerous polymers are employed in biomedical applications, only a few, like poly (e-caprolactone) (PCL), polylactides, etc., are non-toxic and resorbable. PCL, a biodegradable polyester having a low melting temperature and superior viscoelastic properties, represents an ideal candidate for 3D printing. Additive manufacturing (AM) or 3D printing has evolved as a cutting edge manufacturing technology that finds many applications in tissue engineering. Researchers have embraced 3D printing to fabricate PCL composites that find promise in soft and hard tissue engineering. AM allows great deal of freedom in manufacturing complex internal and external geometries with high precision. This review aims to identify the possibilities that the field of AM can contribute towards the development of sustainable, eco-friendly, bio-polymeric systems for biomedical applications with a special emphasis on PCL composites.

中文翻译：

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用于组织工程的聚（ε-己内酯）的增材制造

设计具有可控降解特性和机械和加工特性的聚合物的能力为开发新型聚合物基药物递送装置、缝合线、植入物等开辟了机会。虽然许多聚合物用于生物医学应用，但只有少数聚合物，如聚（ e-己内酯）（PCL）、聚交酯等无毒且可吸收。PCL 是一种具有低熔点和优异粘弹性的可生物降解聚酯，是 3D 打印的理想候选者。增材制造 (AM) 或 3D 打印已发展成为一种尖端制造技术，在组织工程中有许多应用。研究人员已经采用 3D 打印来制造 PCL 复合材料，这些复合材料在软组织和硬组织工程中都有应用。AM 为高精度制造复杂的内部和外部几何形状提供了很大的自由度。本综述旨在确定 AM 领域可以为生物医学应用的可持续、环保、生物聚合物系统的发展做出贡献的可能性，特别强调 PCL 复合材料。