Surgery remains one of the key treatment options for tumour removal, and surgeons primarily rely on eye and touch to assess the boundary between healthy and cancerous tissue with no cellular information as guidance. There is therefore a need for a device or instrument that can be used by the surgeon in real-time during the surgical procedure to ensure as many of the cancerous cells and as few of the healthy cells have been removed as possible. Fluorescence approaches have previously demonstrated significant promise in this application, but clinical take-up has been limited and much more characterization of critical parameters needed before robotic surgery can be contemplated. Here we investigate two time-correlated single-photon counting (TCSPC) fluorescence lifetime systems for the detection of phantom tumour margins derived from silica sol-gels. A simple and low-cost liquid light guide system (LLG) incorporating a single photomultiplier detection channel and translational stag...

中文翻译：

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单通道液体光导耦合和SPAD阵列成像的表征，用于利用荧光寿命估算肿瘤边缘

手术仍然是去除肿瘤的关键治疗方法之一，外科医生主要依靠眼睛和触觉来评估健康和癌性组织之间的边界，而没有细胞信息作为指导。因此，需要外科医生在外科手术过程中实时使用的装置或仪器，以确保尽可能多的癌细胞和健康的细胞被去除。荧光方法先前已证明在该应用中具有重大前景，但临床应用受到限制，可以考虑在进行机器人手术之前对关键参数进行更多的表征。在这里，我们研究了两个时间相关的单光子计数（TCSPC）荧光寿命系统，用于检测衍生自硅溶胶凝胶的幻影肿瘤边缘。