In this work, the synthesis of cobalt Schiff base complex embedded SBA-15 and simultaneous determination of ascorbic acid (ASA), paracetamol (PAR), caffeine (CAF) by square anodic stripping voltammetry (SqW-ASV) are performed. The cobalt Schiff base complex has been derived from salicylaldehyde, 3(-aminopropyl) triethoxysilane, and cobalt acetate. Cobalt Schiff base complex embedded SBA-15 materials was synthesized via anchoring cobalt Schiff base complex on mesoporous SBA-15. Due to the synergetic effects from the cobalt Schiff base complex (excellent electrochemical properties) and SBA-15 (stable and large surface area) the oxidation peak currents of ASA, PAR and CAF on the modified glassy carbon electrode (GCE) are much higher than those on the Schiff base complex/GCE and bare GCE. The modified electrode exhibited an effective catalytic response to the oxidation of ASA, PAR, and CAF with good reproducibility and stability. The modified GCE has a detection limit of 0.085 μM for ASA, 0.059 μM for PAR and 0.032 μM for CAF. The proposed SqW-ASV method was successfully applied in the simultaneous determination of ASA, PAR and CAF in several pharmaceutical preparations, with results similar to those obtained by high-performance liquid chromatography.

在这项工作中，通过方形阳极溶出伏安法 (SqW-ASV) 合成了钴希夫碱配合物嵌入的 SBA-15 并同时测定了抗坏血酸 (ASA)、扑热息痛 (PAR)、咖啡因 (CAF)。钴席夫碱复合物衍生自水杨醛、3（-氨基丙基）三乙氧基硅烷和乙酸钴。通过将钴席夫碱络合物锚定在介孔 SBA-15 上，合成了钴席夫碱络合物嵌入的 SBA-15 材料。由于钴席夫碱配合物（优异的电化学性能）和 SBA-15（稳定和大表面积）的协同作用，ASA、PAR 和 CAF 在改性玻碳电极（GCE）上的氧化峰电流远高于那些在 Schiff base complex / GCE 和裸 GCE 上的。修饰电极对 ASA、PAR 和 CAF 的氧化表现出有效的催化反应，具有良好的重现性和稳定性。修改后的 GCE 检测限为 0.085μ M代表ASA，0.059 μ M代表PAR和0.032 μ M代表CAF。所提出的 SqW-ASV 方法已成功应用于同时测定多种药物制剂中的 ASA、PAR 和 CAF，其结果与高效液相色谱法获得的结果相似。