Aim. To explore the treatment effect of mica on 2,4,6-trinitrobenzenesulfonic acid solution- (TNBS-) induced colitis in mice. Materials and Methods. Thirty male BALB/C mice were randomly divided into the control group, the TNBS group, and the mica group. Control mice were treated with saline solution. Experimental colitis was induced by TNBS (250 mg/kg/d) in the TNBS group and the mica group. After modeling, the mica group was treated with mica (180 mg/kg/d) for 3 days, while the TNBS group continued the treatment with TNBS. All solutions were injected intrarectally. During treatment, body weight and mice activity were monitored daily. After treatment, the colon tissues of mice were collected; angiotensin II (Ang II), angiotensin-converting enzyme 2 (ACE2), angiotensin 1-7 (Ang (1-7)), IL-17A, and IL-10 expression was analyzed by ELISA and immunohistochemistry. Results. Food intake, activity, and body weight gradually decreased in the TNBS group compared to the control group and the mica group (all ). Also, black stool adhesion in the anus and thin and bloody stool were observed in the TNBS group, but not in the other two groups. Moreover, the expression of Ang II, ACE2, Ang (1-7), IL-17A, and IL-10 in the TNBS group increased compared to that in the control group. Compared to the TNBS group, ACE2, Ang (1-7), and IL-10 in the mica group increased, while Ang II and IL-17A decreased (all ). Conclusion. Mica can alleviate TNBS-induced colitis in mice by regulating the inflammation process; it reduces Ang II and IL-17A and increases ACE2, IL-10, and Ang (1-7).

中文翻译：

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云母可以通过减少血管紧张素 II 和 IL-17A 并增加血管紧张素转换酶 2、血管紧张素 1-7 和 IL-10 来缓解小鼠 TNBS 诱导的结肠炎

瞄准。探讨云母对2,4,6-三硝基苯磺酸溶液-(TNBS-)诱导的小鼠结肠炎的治疗作用。材料和方法. 30只雄性BALB/C小鼠随机分为对照组、TNBS组和云母组。用盐水溶液处理对照小鼠。TNBS组和云母组采用TNBS（250 mg/kg/d）诱导实验性结肠炎。造模后，云母组用云母（180 mg/kg/d）处理3天，TNBS组继续用TNBS处理。所有溶液均直肠内注射。在治疗期间，每天监测体重和小鼠活动。处理后收集小鼠结肠组织；通过 ELISA 和免疫组织化学分析血管紧张素 II (Ang II)、血管紧张素转换酶 2 (ACE2)、血管紧张素 1-7 (Ang (1-7))、IL-17A 和 IL-10 的表达。结果. 与对照组和云母组相比，TNBS 组的摄食量、活动量和体重逐渐下降（所有）。TNBS组肛门黑色便粘连及稀便血便，其他两组均未见。此外，与对照组相比，TNBS组中Ang II、ACE2、Ang(1-7)、IL-17A和IL-10的表达增加。与TNBS组相比，云母组ACE2、Ang(1-7)和IL-10升高，而Ang II和IL-17A降低(均）。 结论。云母可通过调节炎症过程缓解TNBS诱导的小鼠结肠炎；它降低 Ang II 和 IL-17A 并增加 ACE2、IL-10 和 Ang (1-7)。