The historical practice of brewing poppy tea for its opioid-like effects is reoccurring with modern-day substance users. We present four postmortem cases with toxicology results that serve as case studies for the potential hazards of poppy tea ingestion. There is limited information regarding the risks of this practice due to the variability of the morphine content of the opium exuded from the plant. While internet tea recipes offer guidance, differences in poppy cultivation, washing, and infusing time are some of the reasons why the beverage may contain inconsistent and clinically significant alkaloid concentrations for each preparation. Variability in opioid tolerance along with additional drugs taken will impact the overall degree of toxicity experienced from the opiates in the tea. Advancements in the genetic modification of the poppy plant could greatly alter the ratio of alkaloids seen in biological fluids and will be highly dependent on the source of the poppy product. The blood concentrations of free morphine and free codeine in cases 1–3 where the toxicity from the tea was considered the primary cause of death were 0.94 and 0.11 mg/L, 0.62 and 0.034 mg/L, and 0.16 and 0.010 mg/L, respectively. The urine concentrations of morphine and codeine were 13 and 0.94 mg/L in case 1 and 16 and 1.6 mg/L in case 2, respectively. The opium alkaloids thebaine and laudanosine were identified qualitatively by our routine organic base/neutral drug detection procedure.

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罂粟茶消费致死

酿造罂粟茶具有类似阿片样物质作用的历史惯例在现代物质使用者中屡见不鲜。我们介绍了四个具有毒理学结果的事后案例，这些案例研究了罂粟茶摄入的潜在危害。由于从植物中渗出的鸦片中吗啡含量的变化，有关这种做法的风险的信息有限。尽管互联网茶食谱提供了指导，但罂粟种植，洗涤和浸泡时间的差异是每种饮料中每种制剂可能含有不一致且临床上有意义的生物碱浓度的一些原因。阿片类药物耐受性的变化以及所服用的其他药物将影响茶中阿片类药物的总体毒性程度。罂粟植物遗传修饰的进展可能会极大地改变生物流体中生物碱的比例，并且将高度依赖于罂粟产品的来源。在第1-3种情况下，认为茶毒性是主要死亡原因的游离吗啡和游离可待因的血药浓度分别为0.94和0.11 mg / L，0.62和0.034 mg / L，0.16和0.010 mg / L，分别。在情况1中，吗啡和可待因的尿液浓度分别为13和0.94 mg / L，在情况2中，分别为16和1.6 mg / L。通过我们常规的有机碱/中性药物检测程序定性鉴定了鸦片生物碱蒂巴因和月桂苷。在第1-3种情况下，认为茶毒性是主要死亡原因的游离吗啡和游离可待因的血药浓度分别为0.94和0.11 mg / L，0.62和0.034 mg / L，0.16和0.010 mg / L，分别。在情况1中，吗啡和可待因的尿液浓度分别为13和0.94 mg / L，在情况2中，分别为16和1.6 mg / L。通过我们常规的有机碱/中性药物检测程序定性鉴定了鸦片生物碱蒂巴因和月桂苷。在第1-3种情况下，认为茶毒性是主要死亡原因的游离吗啡和游离可待因的血药浓度分别为0.94和0.11 mg / L，0.62和0.034 mg / L，0.16和0.010 mg / L，分别。在情况1中，吗啡和可待因的尿液浓度分别为13和0.94 mg / L，在情况2中，分别为16和1.6 mg / L。通过我们常规的有机碱/中性药物检测程序定性鉴定了鸦片生物碱蒂巴因和月桂苷。