Our previous studies have shown that Ogaja Acanthopanax sessiliflorus has an important role in decreasing blood pressure, but its biochemical change characteristic has not been clarified completely at the metabolic level. Therefore, in this study, a combination method of nuclear magnetic resonance (NMR) spectroscopy-based metabonomics and multivariate statistical analyses was employed to explore the metabolic changes of serum samples from spontaneously hypertensive rats treated with Ogaja extracts. In the results of multivariate statistical analysis, the spontaneously hypertensive rat (SHR) groups treated with Ogaja were separated from the SHR group. The group of SHR treated with 200 mg/kg Ogaja was clustered with the positive control (captopril) group, and the 400 and 600 mg/kg Ogaja treatment SHR groups were clustered together. Quantified metabolites were statistically analyzed to find the metabolites showing the effects of Ogaja. Succinate and betaine had variable importance in projection (VIP) scores over 2.0. Succinate, which is related to renin release, and betaine, which is related to lowering blood pressure, increased dose-dependently.

中文翻译：

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Ogaja对自发性高血压大鼠降压作用的血清代谢组学研究

我们以前的研究表明，Ogaja Acanthopanax sessiliflorus在降低血压中起重要作用，但其生化变化特征尚未在代谢水平上完全阐明。因此，在这项研究中，基于核磁共振波谱的代谢组学和多元统计分析的组合方法被用来探讨使用Ogaja提取物治疗的自发性高血压大鼠血清样品的代谢变化。在多元统计分析的结果中，使用Ogaja治疗的自发性高血压大鼠（SHR）组与SHR组分开。用200 mg / kg Ogaja治疗的SHR组与阳性对照（卡托普利）组聚集在一起，将400 mg / kg和600 mg / kg Ogaja治疗的SHR组聚集在一起。对定量代谢物进行统计分析，以发现显示出Ogaja作用的代谢物。琥珀酸和甜菜碱在超过2.0的预测（VIP）得分中具有不同的重要性。琥珀酸与肾素释放有关，甜菜碱与血压降低有关，剂量依赖性增加。