Triggering heart repair after myocardial infarction is a challenge in regenerative medicine. A study now shows how ERBB2-mediated YAP activation promotes both cardiomyocyte proliferation and epithelial-to-mesenchymal transition (EMT) in adult mice. EMT initiates cardiomyocyte dedifferentiation and migration and together with proliferation promotes cardiac regeneration.

中文翻译：

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增殖和 EMT 触发心脏修复

心肌梗塞后触发心脏修复是再生医学中的一个挑战。现在的一项研究显示了 ERBB2 介导的 YAP 激活如何促进成年小鼠的心肌细胞增殖和上皮间质转化 (EMT)。EMT 启动心肌细胞去分化和迁移，并与增殖一起促进心脏再生。