ABSTRACT

An ecofriendly and efficient preparation of a set of a new 1-propylimidazolium-based ionic liquids (1–20) has been manufactured by using both microwave irradiation and conventional procedure. Different spectral analysis (FT-IR, mass spectra, NMR and elemental analysis) were utilized to examine the structures of the newly prepared ILs. The in vitro antitumor activities of all ILs (1–20) were investigated, using viability assay, towards HEPG-2, MCF7 and CACO2 Cells. Among all tested ILs, the 3-(3-phenylpropyl)-1-propyl-1H-imidazol-3-ium tetrafluoroborate (13) showed better activity towards human hepatocellular carcinoma (HEPG-2) and colon carcinoma (CACO2), while the 3-(3-phenoxypropyl)-1-propyl-1H-imidazol-3-ium tetrafluoroborate (20) exhibited low IC₅₀ values against human breast adenocarcinoma (MCF7) compared to the standard drug (5-fluorouracil (5-FU)). Generally, all ILs 1–20 derivatives showed moderate cytotoxic activity against all tested cell lines.

摘要

通过使用微波辐射和常规方法，已经生产了一套环保，高效的新型1-丙基咪唑基离子液体（1–20）。利用不同的光谱分析（FT-IR，质谱，NMR和元素分析）来检查新制备的IL的结构。在体外所有ILS（的抗肿瘤活性1-20）进行了调查，使用生存力测定，朝HEPG-2，MCF7和Caco-2细胞。在所有测试的IL中，3-（3-苯基丙基）-1-丙基-1H-咪唑-3-四氟硼酸（13）对人肝细胞癌（HEPG-2）和结肠癌（CACO2）表现出更好的活性，而3-（3-苯氧基丙基）-1-丙基-1H-咪唑-3-四氟硼酸（20）与标准药物（5-氟尿嘧啶（5-FU））相比，对人乳腺腺癌（MCF7）的IC ₅₀值低。通常，所有ILs 1–20衍生物对所有测试的细胞系均显示中等的细胞毒活性。