Abstract

This study investigated the effect of concurrent training (CT) sequences on fibroblast growth factor 21 (FGF21), irisin, myostatin (MSTN), and follistatin (FST) among adults with type 2 diabetes mellitus (T2DM). Fifty-one diabetic men were randomly selected and assigned to concurrent aerobic-resistance (A-R) training and concurrent resistance-aerobic (R-A) training, and non-exercise control (CON) groups. The training protocols consisted of three sessions per week for 12 weeks. The A-R and R-A groups received the same CT protocols and performed with different sequences. The subjects’ blood samples were obtained at baseline and 48 hours after the last session of the intervention. The results showed that the concentration of FGF21 did not change significantly after the 12 weeks of CT with different sequences (p > .05, η² = 0.123), but the serum concentration of irisin (A-R = 2.93 μg.L^–1 (95% CI = 1.45–4.42, d = −0.57) and R-A = 3.31 μg.L^–1 (95% CI = 1.13–5.49, d = −0.68)) and FST (A-R = 4.96 ng.mL^–1 (95% CI = 3.41–6.5, d = −0.39) and R-A = 4.19 ng.mL^–1 (95% CI = 2.82–5.56, d = –0.55)) significantly increased while the serum MSTN concentration (A-R = 152.32 ng.L^–1 (95% CI = 61.83–242.82, d = 1.31) and R-A = 173 ng.L^–1 (95% CI = 35.89–227.5, d = 0.83)) of both A-R and R-A groups mainly decreased (p < .01). There was no significant difference between A-R and R-A groups’ irisin, FST, and MSTN concentration (p > .05), though the CT improved the body compositions, strength, and peak oxygen uptake in both groups (p < .01). Regardless of the CT sequences, it was found that CT acted as a therapeutic modality of training for T2DM patients by increasing their irisin and FST and decreasing their MSTN concentrations.

摘要

本研究调查了并发训练 (CT) 序列对成年 2 型糖尿病 (T2DM) 成纤维细胞生长因子 21 (FGF21)、鸢尾素、肌肉生长抑制素 (MSTN) 和卵泡抑素 (FST) 的影响。51 名糖尿病男性被随机选择并分配到同步有氧阻力 (AR) 训练和同步阻力有氧 (RA) 训练以及非运动控制 (CON) 组。训练方案包括每周 3 节课，共 12 周。AR 和 RA 组接受相同的 CT 协议并以不同的顺序执行。受试者的血液样本是在基线时和最后一次干预后 48 小时获得的。结果显示，不同序列CT 12周后FGF21浓度无明显变化（p > .05, η ²  = 0.123)，但鸢尾素的血清浓度 (AR = 2.93 μg.L ^–1 (95% CI = 1.45–4.42, d  = −0.57) 和 RA = 3.31 μg.L ^–1 (95 % CI = 1.13–5.49, d  = −0.68)) 和 FST (AR = 4.96 ng.mL ^–1 (95% CI = 3.41–6.5, d  = −0.39) 和 RA = 4.19 ng.mL ^–1 (95% CI = 2.82–5.56, d  = –0.55)) 显着增加而血清 MSTN 浓度 (AR = 152.32 ng.L ^–1 (95% CI = 61.83–242.82, d  = 1.31) 和 RA = 173 ng.L ^–1 (95% CI = 35.89–227.5, d  = 0.83)) AR 和 RA 组主要下降 (p  < .01）。AR 和 RA 组的鸢尾素、FST 和 MSTN 浓度之间没有显着差异 ( p  > .05)，尽管 CT 改善了两组的身体成分、力量和峰值摄氧量 ( p  < .01)。无论 CT 序列如何，都发现 CT 通过增加他们的鸢尾素和 FST 并降低他们的 MSTN 浓度，作为训练 T2DM 患者的治疗方式。