Recent Advances in Polychloromethylation Reactions,Advanced Synthesis & Catalysis

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Recent Advances in Polychloromethylation Reactions
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2020-10-11 , DOI: 10.1002/adsc.202000924
Gao Huang ₁ , Jin‐Tao Yu ₁ , Changduo Pan ₂

Affiliation

Molecules with di‐ or trichloromethyl group are widely existed in natural products and man‐made structures that represent special activities in pharmaceuticals and agrochemicals. Besides, polychloromethyl‐containing compounds are also high valuable intermediates in organic synthesis and also can be used as functional materials. Therefore, significant efforts have been made toward the incorporation of polychloromethyl groups into certain structures. In this field, a variety of polychloromethyl reagents, such as CH₂Cl₂, HCCl₃, CCl₄, TMSCCl₃, TMSCCl₂H, etc. have been utilized as the di‐ or trichloromethyl sources toward polychloromethylated structures through radical, nucleophilic, and other reaction patterns. In this review, we summarized and discussed the recent achievements in the synthesis of polychloromethylated compounds, mainly focused on the employment of different polychloromethyl reagents. Most of the works we investigated were reported after 2010. Mechanism discussions and outlooks were also given.

中文翻译：

聚氯甲基化反应的最新进展

具有二氯或三氯甲基基团的分子广泛存在于天然产物和人造结构中，代表了医药和农药的特殊活性。此外，含聚氯甲基的化合物也是有机合成中有价值的中间体，也可用作功能材料。因此，已经做出了巨大的努力以将聚氯甲基结合到某些结构中。在该领域中，多种多氯甲基试剂，例如CH ₂ Cl ₂，HCCl ₃，CCl ₄，TMSCCl ₃，TMSCCl ₂H等已通过自由基，亲核和其他反应方式用作多氯甲基化结构的二氯或三氯甲基来源。在这篇综述中，我们总结并讨论了在合成多氯甲基化化合物方面的最新成就，主要侧重于使用不同的多氯甲基试剂。我们调查的大多数作品都是在2010年之后报道的。还对机制进行了讨论和展望。

更新日期：2020-10-11

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