Injectable hydrogels for nonsteroidal anti‐inflammatory drugs’ (NSAIDs) delivery to minimize the side effects of NSAIDs and achieve long‐term sustained release at the targeted site of synovial joint are attractive for osteoarthritis therapy, but how to improve its mechanical strength remains a challenge. In this work, a kind of 1D natural clay mineral material, attapulgite (ATP), is introduced to a classical cyclodextrin pseudopolyrotaxane (PPR) system to form a reinforced supramolecular hydrogel for sustained release of diclofenac sodium (DS) due to its rigid, rod‐like morphology, and unique structure, which has great potential in tissue regeneration, repair, and engineering. Investigation on the interior morphology and rheological property of the obtained hydrogel points out that the ATP distributed in PPR hydrogel plays a role similar to the “reinforcement in concrete” and exhibits a positive effect on improving the mechanical properties of PPR hydrogel by regulating their interior morphology from a randomly distributed style to the well‐ordered porous frame structure. The hybrid hydrogels demonstrate good shear‐thinning and thixotropic properties, excellent biocompability, and sustained release behavior both in vitro and in vivo. Furthermore, preliminary in vivo treatment in an acute inflammatory rat model reveals that the ATP hybrid hydrogels present sustained anti‐inflammatory effect.

中文翻译：

---

来自凹凸棒石和环糊精的增强超分子水凝胶用于持续关节内给药

用于非甾体抗炎药（NSAIDs）给药的可注射水凝胶最大限度地减少 NSAIDs 的副作用并在滑膜关节的目标部位实现长期持续释放对骨关节炎治疗具有吸引力，但如何提高其机械强度仍然是一个挑战. 在这项工作中，一种一维天然粘土矿物材料凹凸棒石 (ATP) 被引入经典的环糊精假聚轮烷 (PPR) 系统中，形成增强型超分子水凝胶，由于其刚性的棒状结构，可缓释双氯芬酸钠 (DS)。类似的形态和独特的结构，在组织再生、修复和工程方面具有巨大的潜力。对所得水凝胶的内部形态和流变性能的研究表明，分布在 PPR 水凝胶中的 ATP 起到类似于“混凝土中的钢筋”的作用，通过调节其内部形态对提高 PPR 水凝胶的力学性能具有积极作用从随机分布的样式到有序的多孔框架结构。混合水凝胶在体外和体内均表现出良好的剪切稀化和触变性、优异的生物相容性和缓释行为。此外，在急性炎症大鼠模型中的初步体内治疗表明，ATP 混合水凝胶具有持续的抗炎作用。