The hypoglycemic and renal protective effects of Grifola frondosa polysaccharides in early diabetic nephropathy,Journal of Food Biochemistry

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The hypoglycemic and renal protective effects of Grifola frondosa polysaccharides in early diabetic nephropathy
Journal of Food Biochemistry ( IF 3.5 ) Pub Date : 2020-10-11 , DOI: 10.1111/jfbc.13515
Tao Jiang ₁ , Liang Wang ₁ , Angjie Ma ₁ , Yi Wu ₁ , Qiwen Wu ₁ , Qiulin Wu ₁ , Jianwei Lu ₁ , Tian Zhong ₂

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Grifola frondosa is a basidiomycete polypore fungus. Polysaccharides from G. frondosa (PGF) has recently attracted attention for its various physiological activities including antioxidant, antitumor, and anti‐fatigue effects. In this study, hypoglycemic activity of PGF and its preventive effect against the progression of kidney fibrosis in Diabetic nephropathy (DN) rats were investigated. The results showed that PGF led to a significant decrease in fasting blood glucose levels and an increase in body weight in the treatment group compared with those of model group. Serum biochemical indexes including N‐acetyl‐β‐D‐glucosaminidase (NAG), blood urea nitrogen (BUN), serum creatinine (SCr), and urine microalbumin (u‐mAlb) levels of PGF‐treated group were significantly lower than those of model group. Inflammatory cytokines and renal fibrosis indexes of PGF group were also decreased compared to the model group. The whole results demonstrated the renal‐protective effects of PGF via reducing the inflammatory factor content and preventing renal fibrosis.

中文翻译：

Grifola frondosa多糖对早期糖尿病肾病的降血糖和肾脏保护作用

Grifola frondosa是担子菌的多孔真菌。从多糖灰树花（PGF）最近因其各种生理活性而受到关注，包括抗氧化剂，抗肿瘤和抗疲劳作用。在这项研究中，研究了PGF的降血糖活性及其对糖尿病肾病（DN）大鼠肾脏纤维化进展的预防作用。结果表明，与模型组相比，治疗组的PGF导致空腹血糖水平显着降低，体重增加。PGF治疗组的血清生化指标包括N-乙酰-β-D-氨基葡萄糖苷酶（NAG），血尿素氮（BUN），血清肌酐（SCr）和尿微量白蛋白（u-mAlb）水平显着低于PGF治疗组模型组。与模型组相比，PGF组的炎性细胞因子和肾纤维化指标也降低了。

更新日期：2020-10-11

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