Cytotoxic yohimbine‐type alkaloids from the leaves of Rauvolfia vomitoria,Chemistry & Biodiversity

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Cytotoxic yohimbine‐type alkaloids from the leaves of Rauvolfia vomitoria
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-11-10 , DOI: 10.1002/cbdv.202000647
Guanqun Zhan ₁ , Rongkun Miao ₁ , Fuxin Zhang ₁ , Xingbin Wang ₁ , Xinxin Zhang ₁ , Zengjun Guo ₁

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Two new yohimbine‐type monoterpene indole alkaloids, rauvines A and B, and six known derivatives were obtained from the leaves of R. vomitoria. The structures of rauvines A and B were determined by extensive spectroscopic analyses, 13C‐NMR, and ECD calculations. This is the first time to determine the absolute configurations of yohimbine‐type N‐oxides by quantum chemistry calculations (13C‐NMR and ECD calculations). All the isolates were tested for their cytotoxicity against five human cancer cell lines. Rauvine B showed moderate cytotoxicity on human MCF‐7 breast, SWS80 colon, and A549 lung cancer cell lines with IC50 values of 25.5, 22.6, and 26.0 μM, respectively.

中文翻译：

来自呕吐萝芙木叶的细胞毒性育亨宾型生物碱

从 R. vomitoria 的叶子中获得了两种新的育亨宾型单萜吲哚生物碱，萝卜 A 和 B，以及六种已知的衍生物。通过广泛的光谱分析、13C-NMR 和 ECD 计算确定了萝卜 A 和 B 的结构。这是首次通过量子化学计算（13C-NMR 和 ECD 计算）确定育亨宾型 N-氧化物的绝对构型。测试了所有分离株对五种人类癌细胞系的细胞毒性。Rauvine B 对人 MCF-7 乳腺、SWS80 结肠和 A549 肺癌细胞系显示出中等的细胞毒性，IC50 值分别为 25.5、22.6 和 26.0 μM。

更新日期：2020-11-10

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