Flow Photochemistry for Single‐Chain Polymer Nanoparticle Synthesis,Angewandte Chemie International Edition

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Flow Photochemistry for Single‐Chain Polymer Nanoparticle Synthesis
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-10-12 , DOI: 10.1002/anie.202010429
Or Galant ₁ , Hasan Barca Donmez ₁ , Christopher Barner‐Kowollik ₂ , Charles E. Diesendruck ₁

Affiliation

Single chain polymer nanoparticles (SCNP) are an attractive polymer architecture that provides functions seen in folded biomacromolecules. The generation of SCNPs, however, is limited by the requirement of a high dilution chemical step, necessitating the use of large reactors to produce processable quantities of material. Herein, the chemical folding of macromolecules into SCNPs is achieved in both batch and flow photochemical processes by the previously described photodimerization of anthracene units in polymethylmethacrylate (100 kDa) under UV irradiation at 366 nm. When employing flow chemistry, the irradiation time is readily controlled by tuning the flow rates, allowing for the precise control over the intramolecular collapse process. The flow system provides a route at least four times more efficient for SCNP formation, reaching higher intramolecular cross‐linking ratios five times faster than batch operation.

中文翻译：

流光化学用于单链聚合物纳米颗粒的合成

单链聚合物纳米颗粒（SCNP）是一种有吸引力的聚合物结构，可提供折叠生物大分子中所见的功能。但是，SCNP的生成受到高稀释化学步骤的要求的限制，因此必须使用大型反应器来生产可加工量的材料。本文中，通过先前描述的在366nm的UV辐射下在甲基丙烯酸甲酯（100kDa）中蒽单元的光二聚化，在间歇和流式光化学过程中都实现了将大分子化学折叠成SCNP。当采用流动化学时，通过调节流速可以很容易地控制照射时间，从而可以精确控制分子内的塌陷过程。流动系统为SCNP的形成提供了至少四倍的效率，

更新日期：2020-10-12

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