Biomineralization: An Opportunity and Challenge of Nanoparticle Drug Delivery Systems for Cancer Therapy,Advanced Healthcare Materials

当前位置： X-MOL 学术 › Adv. Healthcare Mater. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Biomineralization: An Opportunity and Challenge of Nanoparticle Drug Delivery Systems for Cancer Therapy
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-10-11 , DOI: 10.1002/adhm.202001117
Weicai Wang ₁ , Xiaofan Liu ₁ , Xiangjiang Zheng ₁ , Hyung Jong Jin ₂ , Xuemei Li ₁

Affiliation

Biomineralization is a common process in organisms to produce hard biomaterials by combining inorganic ions with biomacromolecules. Multifunctional nanoplatforms are developed based on the mechanism of biomineralization in many biomedical applications. In the past few years, biomineralization‐based nanoparticle drug delivery systems for the cancer treatment have gained a lot of research attention due to the advantages including simple preparation, good biocompatibility, degradability, easy modification, versatility, and targeting. In this review, the research trends of biomineralization‐based nanoparticle drug delivery systems and their applications in cancer therapy are summarized. This work aims to promote future researches on cancer therapy based on biomineralization. Rational design of nanoparticle drug delivery systems can overcome the bottleneck in the clinical transformation of nanomaterials. At the same time, biomineralization has also provided new research ideas for cancer treatment, i.e., targeted therapy, which has significantly better performance.

中文翻译：

生物矿化：用于癌症治疗的纳米药物递送系统的机遇与挑战

生物矿化是有机体通过将无机离子与生物大分子结合来生产坚硬生物材料的常见过程。在许多生物医学应用中，基于生物矿化的机理开发了多功能纳米平台。在过去的几年中，基于生物矿化的纳米颗粒药物递送系统由于其制备简单，生物相容性好，可降解，易于修饰，多功能性和靶向性等优点而受到了许多研究关注。在这篇综述中，总结了基于生物矿化的纳米药物递送系统的研究趋势及其在癌症治疗中的应用。这项工作旨在促进基于生物矿化的癌症治疗的未来研究。合理设计纳米颗粒药物传递系统可以克服纳米材料临床转化的瓶颈。同时，生物矿化也为癌症治疗提供了新的研究思路，即靶向治疗，具有明显更好的性能。

更新日期：2020-11-18

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11