当前位置: X-MOL 学术Neurobiol. Learn. Mem. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A brief period of sleep deprivation negatively impacts the acquisition, consolidation, and retrieval of object-location memories
Neurobiology of Learning and Memory ( IF 2.2 ) Pub Date : 2020-10-12 , DOI: 10.1016/j.nlm.2020.107326
Pim R A Heckman 1 , Femke Roig Kuhn 1 , Peter Meerlo 1 , Robbert Havekes 1
Affiliation  

Memory is a cognitive concept and refers to the storage of information over a longer time period. It exists of a series of complementary processes; acquisition, consolidation, and retrieval. Each of these processes has its own partly unique neurobiological signature. Sleep deprivation is known to impair hippocampus-dependent long-term memories. Many studies have used extended periods of wakefulness, affecting all three memory processes, thereby making it unable to determine how each of the processes is affected by sleep loss, separately. Others have extensively examined the effects on memory consolidation, showing the detrimental effect of sleep deprivation during the consolidation process on memory formation. Few studies have investigated how memory acquisition and its retrieval are affected by sleep loss. In the present study, we therefore assessed in mice how sleep deprivation negatively impacts memory acquisition, consolidation, and retrieval, in the Object Location Memory task. Mice were sleep deprived for six hours at the beginning of the light phase using the gentle handling method, 1) directly preceding the learning trial (acquisition), 2) immediately after the learning trial (consolidation), or 3) directly preceding the test trial (retrieval). Memory was assessed at either a 24-h or 1-h interval. Using this approach, we show for the first time that six hours of sleep deprivation attenuates the acquisition, consolidation, and retrieval of object-location memories in mice.



中文翻译:

短暂的睡眠剥夺会对物体位置记忆的获取、巩固和检索产生负面影响

记忆是一个认知概念,是指在较长时间内存储信息。它存在一系列互补的过程;获取、合并和检索。这些过程中的每一个都有其部分独特的神经生物学特征。众所周知,睡眠剥夺会损害依赖海马体的长期记忆。许多研究使用了长时间的清醒,影响了所有三个记忆过程,因此无法分别确定每个过程如何受到睡眠不足的影响。其他人已经广泛研究了对记忆巩固的影响,表明在巩固过程中睡眠剥夺对记忆形成的不利影响。很少有研究调查睡眠不足如何影响记忆的获得和恢复。在目前的研究中,因此,我们在小鼠中评估了睡眠剥夺如何在对象位置记忆任务中对记忆获取、巩固和检索产生负面影响。使用温和处理方法,小鼠在光照阶段开始时被剥夺睡眠 6 小时,1) 直接在学习试验 (获取) 之前,2) 在学习试验 (巩固) 之后立即,或 3) 直接在测试试验之前(恢复)。记忆力以 24 小时或 1 小时为间隔进行评估。使用这种方法,我们首次表明,六小时的睡眠剥夺会减弱小鼠对物体位置记忆的获取、巩固和检索。使用温和处理方法,小鼠在光照阶段开始时被剥夺睡眠 6 小时,1) 直接在学习试验 (获取) 之前,2) 在学习试验 (巩固) 之后立即,或 3) 直接在测试试验之前(恢复)。记忆力以 24 小时或 1 小时为间隔进行评估。使用这种方法,我们首次表明,六小时的睡眠剥夺会减弱小鼠对物体位置记忆的获取、巩固和检索。使用温和处理方法,小鼠在光照阶段开始时被剥夺睡眠 6 小时,1) 直接在学习试验 (获取) 之前,2) 在学习试验 (巩固) 之后立即,或 3) 直接在测试试验之前(恢复)。记忆力以 24 小时或 1 小时为间隔进行评估。使用这种方法,我们首次表明,六小时的睡眠剥夺会减弱小鼠对物体位置记忆的获取、巩固和检索。

更新日期:2020-10-16
down
wechat
bug