Disabled-2 (Dab2/DOC-2) is a mitogen-responsive adaptor protein required for multiple cellular functions. It is involved in many signaling pathways and plays an integral role in vesicular uptake and trafficking, modulating immune function, protein-protein interactions, cellular homeostasis and differentiation, oncogenesis, and inflammatory processes in organ systems. It contains domains for binding to NPXY motif-containing and SH3 domain-containing adapter proteins, phosphoinositides, glycoprotein 100 (gp100, or megalin), integrins, clathrin, and myosin VI. However, the molecular mechanism(s) of Dab2’s biological function still remain to be elucidated. In this review, we provide an extensive up-to-date understanding of the function of Dab2 and its regulation in cardiovascular diseases, immune disorders, tumorigenesis, and central nervous system disorders.

Disabled-2（Dab2 / DOC-2）是多种细胞功能所需的促分裂原应答性衔接蛋白。它参与许多信号通路，并在水泡摄取和运输，调节免疫功能，蛋白质-蛋白质相互作用，细胞稳态和分化，肿瘤发生以及器官系统的炎症过程中起着不可或缺的作用。它包含与包含NPXY基序和包含SH3域的衔接蛋白，磷酸肌醇，糖蛋白100（gp100或meg​​alin），整联蛋白，网格蛋白和肌球蛋白VI结合的结构域。然而，Dab2的生物学功能的分子机制仍然有待阐明。在这篇综述中，我们提供了Dab2的功能及其在心血管疾病，免疫疾病，肿瘤发生，