The Y Box binding protein 1 (YB-1) belongs to the highly conserved Cold Shock Domain protein family and is a major component of messenger ribonucleoprotein particles (mRNPs) in various organisms and cells. Cold Shock proteins are multifunctional nucleic acids binding proteins involved in a variety of cellular functions. Biological activities of YB-1 range from the regulation of transcription, splicing and translation, to the orchestration of exosomal RNA content. The role of YB-1 in malignant cell transformation and fate transition is the subject of intensive investigation. Besides, emerging evidence indicates that YB-1 participates in several DNA damage repair pathways as a non-canonical DNA repair factor thus pointing out that the protein can allow cancer cells to evade conventional anticancer therapies and avoid cell death. Here, we will attempt to collect and summarize the current knowledge on this subject and provide the basis for further lines of inquiry.

Y Box结合蛋白1（YB-1）属于高度保守的Cold Shock Domain蛋白家族，是各种生物和细胞中信使核糖核蛋白颗粒（mRNPs）的主要成分。Cold Shock蛋白是涉及多种细胞功能的多功能核酸结合蛋白。YB-1的生物活性从转录，剪接和翻译的调控到外泌体RNA含量的协调。YB-1在恶性细胞转化和命运转变中的作用是深入研究的主题。此外，新出现的证据表明YB-1作为非经典的DNA修复因子参与了几种DNA损伤修复途径，因此指出该蛋白可以使癌细胞逃避常规的抗癌治疗并避免细胞死亡。这里，