Performance in verbal fluency tasks are widely used as a marker of cognitive impairment in Parkinson disease. However, the anatomical substrate of its impairment remains undetermined. Based on the dual-stream language model, we hypothesized cortical input to the subcortical circuitry would be a crucial determinant of fluency. We performed a retrospective study using individual whole-brain structural connectomes derived from 135 individuals with PD and assessed the relationship between white matter integrity and verbal fluency tasks. Controlling for multiple factors, including dysarthria, we observed higher integrity of dorsal stream-caudate connectivity was associated with better letter fluency. This preliminary study indicates the possible dissociation between dorsal and ventral stream connectivity and letter fluency in PD. In addition, it suggests a non-motor role of the frontostriatal fibers in letter fluency.

语言流畅性任务的表现被广泛用作帕金森病认知障碍的标志。然而，其损伤的解剖学基础仍未确定。基于双流语言模型，我们假设皮层下电路的皮层输入将是流畅度的关键决定因素。我们使用来自 135 名 PD 个体的个体全脑结构连接组进行了一项回顾性研究，并评估了白质完整性与语言流畅性任务之间的关系。控制包括构音障碍在内的多种因素，我们观察到背侧尾流 - 尾状核连接的更高完整性与更好的字母流畅性相关。这项初步研究表明背侧和腹侧流连通性与 PD 中的字母流畅性之间可能存在分离。此外，