Abstract

A novel series of imidazo [1,2-a]pyridine derivatives has been designed, synthesized and tested for the anti-proliferative activity against three different human cancer cell lines. Most of the synthesized compounds exhibit anti-proliferative activity with IC₅₀ values ranging from 5.35–59.8 μM. Six compounds demonstrate efficient inhibition of growth of all cell lines with IC₅₀ values close to that of standard drug, and the compound 16h is more potent than the standard drug cisplatin for the HeLa cell line.

中文翻译：

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新型咪唑并[1,2-a]吡啶衍生物的设计，合成，抗癌活性和计算机研究

摘要

已经设计，合成和测试了一系列新颖的咪唑并[1,2- a ]吡啶衍生物，其针对三种不同的人类癌细胞系的抗增殖活性。大多数合成的化合物都具有抗增殖活性，IC ₅₀值为5.35–59.8μM。六种化合物表现出对所有细胞系生长的有效抑制，其IC ₅₀值接近标准药物，并且对于HeLa细胞系，化合物16h比标准药物顺铂更有效。