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Design, Synthesis, Anti-Cancer Activity, and in silico Studies of Novel Imidazo[1,2- a ]pyridine Derivatives
Russian Journal of General Chemistry ( IF 0.9 ) Pub Date : 2020-10-12 , DOI: 10.1134/s1070363220090212
S. Endoori , K. C. Gulipalli , S. Bodige , J. N. Narendra Sharath Chandra , N. Seelam

Abstract

A novel series of imidazo [1,2-a]pyridine derivatives has been designed, synthesized and tested for the anti-proliferative activity against three different human cancer cell lines. Most of the synthesized compounds exhibit anti-proliferative activity with IC50 values ranging from 5.35–59.8 μM. Six compounds demonstrate efficient inhibition of growth of all cell lines with IC50 values close to that of standard drug, and the compound 16h is more potent than the standard drug cisplatin for the HeLa cell line.



中文翻译:

新型咪唑并[1,2-a]吡啶衍生物的设计,合成,抗癌活性和计算机研究

摘要

已经设计,合成和测试了一系列新颖的咪唑并[1,2- a ]吡啶衍生物,其针对三种不同的人类癌细胞系的抗增殖活性。大多数合成的化合物都具有抗增殖活性,IC 50值为5.35–59.8μM。六种化合物表现出对所有细胞系生长的有效抑制,其IC 50值接近标准药物,并且对于HeLa细胞系,化合物16h比标准药物顺铂更有效。

更新日期:2020-10-12
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