Abstract

New sugar hydrazones and their derived oxadiazolyl acyclic nucleoside analogs in addition to the derived thioglycosides incorporating pyridine, furan or thiophene have been synthesized via a multi-component reaction (MCR). The acetylated derivatives of hydrazones and the derived deprotected thioglycosides of the prepared acetylated analogs have been also synthesized. Anticancer activity of the products has been tested against adenocarcinomic human alveolar basal epithelial (A549), human prostatic adenocarcinoma (PC3) and human colorectal carcinoma (HCT116) cell lines in addition to their effect on human normal retinal pigmented epithelial cell line (RPE1) using the MTT assay. Three products: acid hydrazide, sugar hydrazine and glycoside are characterized by high activity against three cancer cell lines.

中文翻译：

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新型吡啶-噻吩和吡啶-呋喃杂化化合物，其糖Hy和糖基衍生物的合成及抗癌活性

摘要

除了衍生的掺入吡啶，呋喃或噻吩的硫代糖苷外，还通过多组分反应（MCR）合成了新的糖及其衍生的恶二唑基无环核苷类似物。还合成了的乙酰化衍生物和制备的乙酰化类似物的衍生的脱保护的硫代糖苷。该产品对腺癌的人肺泡基底上皮细胞（A549），人前列腺腺癌（PC3）和人结肠直肠癌（HCT116）细胞系，除了对人正常视网膜色素上皮细胞系（RPE1）产生影响外，还已经测试了其抗癌活性MTT分析。三种产物：酰肼，糖肼和糖苷的特征在于对三种癌细胞系具有高活性。